RT Journal Article
SR Electronic
T1 Liver histology in patients receiving low dose pulse methotrexate for the treatment of rheumatoid arthritis.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 591
OP 593
DO 10.1136/ard.49.8.591
VO 49
IS 8
A1 R F Willkens
A1 P A Leonard
A1 D O Clegg
A1 K G Tolman
A1 J R Ward
A1 C R Marks
A1 M L Greene
A1 G J Roth
A1 C G Jackson
A1 G W Cannon
YR 1990
UL http://ard.bmj.com/content/49/8/591.abstract
AB The liver histology of 52 patients treated with intermittent low dose pulse methotrexate for rheumatoid arthritis was evaluated using a modification of the Roenigk grading system. Patients studied had had an average of 3.2 years of treatment or had received 1.7 g methotrexate. No patient had cirrhosis; 15 (29%) patients had evidence of mild fibrosis. Histological abnormalities were not predicted by liver function test changes, with the exception that hypoalbuminaemia occurred in 60% of those with grade IV (modified criteria) findings. The need for liver biopsy in patients with rheumatoid arthritis treated with methotrexate before two years or 1500 mg of treatment has not been established. Whether serial liver biopsies will be needed beyond this time has yet to be determined.