RT Journal Article
SR Electronic
T1 Pancytopenia related to azathioprine in rheumatoid arthritis.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 503
OP 505
DO 10.1136/ard.47.6.503
VO 47
IS 6
A1 M E Jeurissen
A1 A M Boerbooms
A1 L B van de Putte
YR 1988
UL http://ard.bmj.com/content/47/6/503.abstract
AB Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily. In one patient this side effect occurred after three weeks, in the other after eight weeks of treatment. Rapid fall of platelets in one patient necessitated platelet transfusion. In the other patient additional treatment with allopurinol was probably responsible for the toxic effect. Haematological side effects of azathioprine are discussed.