RT Journal Article
SR Electronic
T1 Immunoglobulin allotype Gm(1,2;21) in ankylosing spondylitis with peripheral arthritis.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 893
OP 897
DO 10.1136/ard.47.11.893
VO 47
IS 11
A1 Mierau, R
A1 von Mühlen, C A
A1 Zarnowski, H
A1 Genth, E
A1 Hartl, P W
YR 1988
UL http://ard.bmj.com/content/47/11/893.abstract
AB Frequencies of immunoglobulin G (Gm) allotypes were determined in 240 patients with ankylosing spondylitis (AS). The uncommon phenotype Gm(1,2;21) was increased in frequency in 55 patients with AS and peripheral arthritis (14.5% v 3.5% of healthy blood donors; p less than 0.05). In 16 patients with arthritis only of wrist/hand or ankle/forefoot, or both, the Gm(1,2;21) frequency was even higher (31.3%; p less than 0.0005). Patients with AS negative for the HLA antigen B27 (n = 28) differed from the B27 positive patients (n = 205) with regard to the frequency of the Gm(1,2,3;5,21) phenotype (39.3% v 9.3%; p less than 0.0005). These findings support the notion of genetic heterogeneity among patients with AS.