RT Journal Article
SR Electronic
T1 Xanthine oxidoreductase is present in human synovium.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 843
OP 845
DO 10.1136/ard.46.11.843
VO 46
IS 11
A1 Allen, R E
A1 Outhwaite, J M
A1 Morris, C J
A1 Blake, D R
YR 1987
UL http://ard.bmj.com/content/46/11/843.abstract
AB It is postulated that the mobile inflamed joint may be subject to cyclical ischaemic reperfusion injury. Xanthine oxidoreductase is an enzyme thought to contribute to oxidative reperfusion injury, and the detection of this activity in human synovium is described. Three normal and five rheumatoid tissues were assayed with a carbon-14 radioassay detecting the conversion of [14C]xanthine to [14C]uric acid. Rheumatoid synovia contained 0.67-305 microU/g tissue (n = 5), while normal synovia contained 1.2-5.0 microU/g tissue (n = 3).