RT Journal Article
SR Electronic
T1 Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen changes that reflect activation.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 34
OP 39
DO 10.1136/ard.47.1.34
VO 47
IS 1
A1 P Emery
A1 A F Lopez
A1 G F Burns
A1 M A Vadas
YR 1988
UL http://ard.bmj.com/content/47/1/34.abstract
AB The level of expression of surface antigens was studied on neutrophils from paired samples of blood and synovial fluid of patients with rheumatoid arthritis (RA). By measuring the immunofluorescence of labelled monoclonal antibodies it was shown that on joint neutrophils there was an increase in expression of complement receptor 3 (CR3) and granulocyte functional antigens 1 and 2 compared with blood neutrophils, whereas the expression of GpIIb-IIIa was reduced. The pattern of expression was the same as that seen with in vitro activation and strongly suggest that activation is occurring within the joint.