PT  - JOURNAL ARTICLE
AU  - R M Bernstein
AU  - S H Morgan
AU  - C C Bunn
AU  - R C Gainey
AU  - G R Hughes
AU  - M B Mathews
TI  - The SL autoantibody-antigen system: clinical and biochemical studies.
AID  - 10.1136/ard.45.5.353
DP  - 1986 May 01
TA  - Annals of the Rheumatic Diseases
PG  - 353--358
VI  - 45
IP  - 5
4099  - http://ard.bmj.com/content/45/5/353.short
4100  - http://ard.bmj.com/content/45/5/353.full
SO  - Ann Rheum Dis1986 May 01; 45
AB  - A recently described autoantibody, SL, was found in serum from 27 patients with autoimmune disease, including 20 with systemic lupus erythematosus (SLE) where the frequently was 7%. Analysis of clinical, serological, and HLA data from 119 SLE patients showed no positive associations with anti-SL antibody apart from a higher frequency of non-infective fever. Most SL positive sera contained other precipitins, notably antibodies to Ro(SS-A) and the proliferating cell nuclear antigen, PCNA. Anti-SL IgG recognised a protein of 32 000 daltons without associated RNA. This polypeptide was distinguished from a similarly sized component of the Sm and RNP ribonucleoprotein particles by demonstrating different products of partial proteolysis. Although anti-SL antibody is of limited clinical importance, it occurs with twice the frequency of anti-SM antibody in white patients with SLE. Preliminary studies indicate that SL and the Japanese Ki system are identical.