TY - JOUR T1 - Demonstration of an abnormality of C apoprotein of very low density lipoprotein in patients with gout. JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 390 LP - 394 DO - 10.1136/ard.44.6.390 VL - 44 IS - 6 AU - D G Macfarlane AU - C A Midwinter AU - P A Dieppe AU - C H Bolton AU - M Hartog Y1 - 1985/06/01 UR - http://ard.bmj.com/content/44/6/390.abstract N2 - The very low density (VLDL) apolipoproteins of 12 male patients with gout have been studied by analytical isoelectric focusing. The relative percentage distribution of the C apolipoproteins was calculated and compared with that from 12 normolipidaemic and 12 'lipid-matched' controls. In the gout patients apolipoprotein CII (apo CII) represented 19.6% of the VLDL C proteins and the CII/CIII2 ratio was 0.57. In the normolipidaemic controls apo CII represented 28.8% and in the lipid-matched controls 33.1% of VLDL apo C, and the CII/CIII2 ratio approached one in each control group. These differences were significant. This suggests that a reduction in VLDL apo CII may predispose to the hypertriglyceridaemia that is commonly found in patients with gout. ER -