PT  - JOURNAL ARTICLE
AU  - Jubb, R W
TI  - Differential responses of human articular cartilage to retinol.
AID  - 10.1136/ard.43.6.833
DP  - 1984 Dec 01
TA  - Annals of the Rheumatic Diseases
PG  - 833--840
VI  - 43
IP  - 6
4099  - http://ard.bmj.com/content/43/6/833.short
4100  - http://ard.bmj.com/content/43/6/833.full
SO  - Ann Rheum Dis1984 Dec 01; 43
AB  - An in-vitro study has been made of the response of aged human articular cartilage to the catabolic agent retinol. Weight bearing cartilage from the femoral condyle degrades and releases proteoglycan with an associated reduction of sulphate incorporation. Similar cartilage from the femoral head responds to the retinol with an inhibition of sulphate incorporation but no degradation or loss of proteoglycan. Extraction of the proteoglycan from the femoral head samples failed to demonstrate any evidence of breakdown.