PT - JOURNAL ARTICLE AU - Schiff, B AU - Mizrachi, Y AU - Orgad, S AU - Yaron, M AU - Gazit, E TI - Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis. AID - 10.1136/ard.41.4.403 DP - 1982 Aug 01 TA - Annals of the Rheumatic Diseases PG - 403--404 VI - 41 IP - 4 4099 - http://ard.bmj.com/content/41/4/403.short 4100 - http://ard.bmj.com/content/41/4/403.full SO - Ann Rheum Dis1982 Aug 01; 41 AB - Forty-nine Israeli Jewish patients with rheumatoid arthritis (RA) were studied for their HLA A, B, C, DR antigen frequency. A significant increase in HLA Aw31 and HLA DR1 was observed (p less than 5.10(-5) and p less than 5.10(-3) respectively). 45% of Aw31 positive patients were sero-negative for rheumatoid factor, while most HLA DR1 positive individuals were seropositive. DR5 was found to be significantly decreased (p less than 5.10(-4)). Contrary to previous reports, DRw4 was found to be within the range of antigen frequency of the controls (34.7% vs. 32%). It is suggested that in our population of patients Aw31 and DR1 and not DR4 are highly associated with adult onset of RA.