RT Journal Article SR Electronic T1 Long-term azathioprine in rheumatoid arthritis: a double-blind study. JF Annals of the Rheumatic Diseases JO Ann Rheum Dis FD BMJ Publishing Group Ltd and European League Against Rheumatism SP 560 OP 563 DO 10.1136/ard.40.6.560 VO 40 IS 6 A1 M De Silva A1 B L Hazleman YR 1981 UL http://ard.bmj.com/content/40/6/560.abstract AB Several studies have demonstrated the beneficial effect of azathioprine in rheumatoid arthritis. But fears have been expressed about the possible mutagenic and teratogenic effects of prolonged use. If the drug could be withdrawn once remission is achieved, and this remission be then maintained with other agents, the possible complications of long-term therapy might be avoided. A double-blind controlled study was carried out over 8 months in 32 patients receiving long-term azathioprine therapy for rheumatoid arthritis. Substitution of placebo for active drug resulted in clinical deterioration.