TY - JOUR T1 - Systemic lupus erythematosus in childhood. JF - Annals of the Rheumatic Diseases JO - Ann Rheum Dis SP - 325 LP - 331 DO - 10.1136/ard.40.4.325 VL - 40 IS - 4 AU - F Caeiro AU - F M Michielson AU - R Bernstein AU - G R Hughes AU - B M Ansell Y1 - 1981/08/01 UR - http://ard.bmj.com/content/40/4/325.abstract N2 - The clinical and serological features have been analysed retrospectively in 42 patients with an onset of systemic lupus erythematosus (SLE) up to 16 years of age. Thirty-seven (88.1%) were female and 5 (11.9%) male. The mean age of onset was 12.3 years (range 7-16); 11 patients were 10 years or under. The mean duration of disease from diagnosis was 7.1 years (range 6 months-25 years). There were 6 deaths, 3 from infection, 2 from renal failure, and 1 from heart failure. Survival was calculated both from the date of onset and from the date of diagnosis. With the latter the estimated overall survival at 5 years was 82.6% and at 10 years 76.1%. The survival for patients with lupus nephritis was 59.5% at 5 years and 47.6% at 10 years. These data suggests that SLE in childhood is not necessarily associated with a poor prognosis, though renal involvement is still serious. There appeared to be no major differences between prepubertal, adolescent, and adult SLE with respect to clinical and serological findings. ER -