RT Journal Article
SR Electronic
T1 Immunoprotein deposition in synovial tissue in Reiter's syndrome.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 281
OP 285
DO 10.1136/ard.40.3.281
VO 40
IS 3
A1 Baldassare, A R
A1 Weiss, T D
A1 Tsai, C C
A1 Arthur, R E
A1 Moore, T L
A1 Zuckner, J
YR 1981
UL http://ard.bmj.com/content/40/3/281.abstract
AB The aetiology of Reiter's syndrome (RS) is unknown. In order to evaluate the role of immunological mechanisms in this disease we performed synovial biopsies on 12 patients with RS looking for deposition of immunoglobulins and complement components in synovial tissue. By immunofluorescent techniques 11 synovia were found to have immunoprotein deposition. IgM deposition was found around vessels in 8 synovia and in the interstitial tissue in 4. C3 was present perivascularly in 11 cases; in 4 of those there was also staining in the interstitial tissue. No immunoproteins were found in infiltrating or synovial lining cells. The finding of immunoproteins in the synovium of the majority of patients with RS suggests that immunological mechanisms are involved in the pathogenesis of this disease.