PT  - JOURNAL ARTICLE
AU  - Minns, R J
AU  - Steven, F S
TI  - Local denaturation of collagen fibres during the mechanical rupture of collagenous fibrous tissue.
AID  - 10.1136/ard.39.2.164
DP  - 1980 Apr 01
TA  - Annals of the Rheumatic Diseases
PG  - 164--167
VI  - 39
IP  - 2
4099  - http://ard.bmj.com/content/39/2/164.short
4100  - http://ard.bmj.com/content/39/2/164.full
SO  - Ann Rheum Dis1980 Apr 01; 39
AB  - Human extensor tendons of the hand were pulled to rupture, and the torn ends, when observed in the scanning electron microscope, appeared to be knotted, possibly owing to the denaturation of the collagen. This confirmed by fluorimetry assays of both the ruptured ends and the middle unbroken sections of the same tendons. The use of a proteolytic enzyme, trypsin, to remove the denatured material and enhance the repair of organised collagen fibres from both ends is suggested if the ruptured ends have the denatured knotted appearance commonly observed clinically.