RT Journal Article
SR Electronic
T1 Allopurinol treatment and its effect on renal function in gout: a controlled study.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 59
OP 65
DO 10.1136/ard.41.1.59
VO 41
IS 1
A1 T Gibson
A1 V Rodgers
A1 C Potter
A1 H A Simmonds
YR 1982
UL http://ard.bmj.com/content/41/1/59.abstract
AB Fifty-nine patients with primary gout were treated with either a combination of colchicine and allopurinol or colchicine alone. Assessments of renal function over 2 years revealed a statistically significant fall of glomerular filtration rate an urine concentrating ability in those receiving only colchicine. The renal function of patients given allopurinol did not change. Treatment with allopurinol resulted ina significant reduction of ammonium excretion, a phenomenon which could not be readily explained. Urate clearance also declined during allopurinol treatment, and the impaired urate clearance associated with gout became more evident. The most important observation was that allopurinol retarded an apparent decline of renal function. Presumably this was achieved through its hypouricaemic effect and implies that the hyperuricaemia of gouty patients is deleterious to the kidneys.