RT Journal Article
SR Electronic
T1 Morphea-like reaction to D-penicillamine therapy.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 42
OP 44
DO 10.1136/ard.40.1.42
VO 40
IS 1
A1 R M Bernstein
A1 M A Hall
A1 B E Gostelow
YR 1981
UL http://ard.bmj.com/content/40/1/42.abstract
AB We report the case of a 48-year-old woman who developed morphea-like plaques after 1 year of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 months. The histological appearance was of increased dermal fibrosis with an inflammatory infiltrate round dermal capillaries. However, epidermal changes were not typical of morphea. New lesions ceased to appear within a few months of stopping penicillamine, and by 1 year all the plaques were pale and symptomless.