PT  - JOURNAL ARTICLE
AU  - J Steinberg
AU  - C B Sledge
AU  - J Noble
AU  - H G Gillies
TI  - Dextran sulphate induced arthritis in rabbits.
AID  - 10.1136/ard.39.4.387
DP  - 1980 Aug 01
TA  - Annals of the Rheumatic Diseases
PG  - 387--391
VI  - 39
IP  - 4
4099  - http://ard.bmj.com/content/39/4/387.short
4100  - http://ard.bmj.com/content/39/4/387.full
SO  - Ann Rheum Dis1980 Aug 01; 39
AB  - Persistent effects of a short course of intra-articular dextran sulphate, dextrans, or chondroitin sulphate were examined in rabbit knees. Only dextran sulphate produced gross arthritis, associated with high synovial acid phosphatase and beta-glucuronidase activities. Synovial degradative capacity in synovium-cartilage cocultures was increased 2-fold by dextran sulphate and 1.5-fold by chondroitin sulphate treatments. Stimulation of cartilage breakdown in vitro paralleled the content of synovial marker enzyme at death of the animal, but the 2 responses could be dissociated.