RT Journal Article
SR Electronic
T1 Controlled inpatient study of tienilic acid in treatment of gout and hypertension.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 367
OP 372
DO 10.1136/ard.39.4.367
VO 39
IS 4
A1 J A Reardon
A1 J T Scott
YR 1980
UL http://ard.bmj.com/content/39/4/367.abstract
AB Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50% in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single morning dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency. The single daily regimen produced greater diurnal fluctuations in plasma urate and was more frequently associated with the development of acute gout attacks.