RT Journal Article
SR Electronic
T1 Cellular immunity in systemic lupus erythematosus as evidenced in vitro by leucocyte migration inhibition tests.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 433
OP 441
DO 10.1136/ard.36.5.433
VO 36
IS 5
A1 Okubo, M
A1 Nagura, Y
A1 Pompa, D
A1 Treser, G
A1 Lange, K
YR 1977
UL http://ard.bmj.com/content/36/5/433.abstract
AB A leucocyte migration inhibition test was performed on 26 patients with systemic lupus erythematosus (SLE) and on 35 control subjects using three different antigens, fetal calf thymus DNA, baker's yeast RNA, and calf thymus extractable nuclear antigen (ENA). Leucocyte migration was inhibited by DNA in 17 out of 26 SLE patients (65-3%), and in only 2 of the 35 controls (5-7%). When RNA or ENA was added none of the patients or controls showed inhibition. In SLE patients migration inhibition by DNA was significantly correlated with the presence of proteinuria and/or granular casts in urinary sediment. When the migration inhibition test was positive, immunofluorescence verified active histology of the glomeruli obtained by a percutaneous renal biopsy.