RT Journal Article
SR Electronic
T1 Altered phospholipids in human rheumatoid synoviocytes.
JF Annals of the Rheumatic Diseases
JO Ann Rheum Dis
FD BMJ Publishing Group Ltd and European League Against Rheumatism
SP 24
OP 29
DO 10.1136/ard.37.1.24
VO 37
IS 1
A1 Henderson, B
A1 Bitensky, L
A1 Chayen, J
YR 1978
UL http://ard.bmj.com/content/37/1/24.abstract
AB A specific cytochemical reaction for freely available phospholipids has shown a raised concentration of such phospholipids in the lining cells of human synovial membranes removed from rheumatoid joints. Quantitative measurement, by microdensitometry, of the amount of reaction-product per cell showed that the rheumatoid synoviocytes contained almost three times the amount of free phospholipids present in the equivalent nonrheumatoid cells; statistically the difference was highly significant. Evidence from studies in which the bound phospholipids were 'unmasked' by methanol-chloroform confirmed the view that the increased content of freely available phospholipids was related to altered lipid-protein binding rather than to an increase in total phospholipids.