PT  - JOURNAL ARTICLE
AU  - Henderson, B
AU  - Bitensky, L
AU  - Chayen, J
TI  - Altered phospholipids in human rheumatoid synoviocytes.
AID  - 10.1136/ard.37.1.24
DP  - 1978 Feb 01
TA  - Annals of the Rheumatic Diseases
PG  - 24--29
VI  - 37
IP  - 1
4099  - http://ard.bmj.com/content/37/1/24.short
4100  - http://ard.bmj.com/content/37/1/24.full
SO  - Ann Rheum Dis1978 Feb 01; 37
AB  - A specific cytochemical reaction for freely available phospholipids has shown a raised concentration of such phospholipids in the lining cells of human synovial membranes removed from rheumatoid joints. Quantitative measurement, by microdensitometry, of the amount of reaction-product per cell showed that the rheumatoid synoviocytes contained almost three times the amount of free phospholipids present in the equivalent nonrheumatoid cells; statistically the difference was highly significant. Evidence from studies in which the bound phospholipids were 'unmasked' by methanol-chloroform confirmed the view that the increased content of freely available phospholipids was related to altered lipid-protein binding rather than to an increase in total phospholipids.