PT - JOURNAL ARTICLE AU - Mowat, A G TI - Neutrophil chemotaxis in rheumatoid arthritis. Effect of D-penicillamine, gold salts, and levamisole. AID - 10.1136/ard.37.1.1 DP - 1978 Feb 01 TA - Annals of the Rheumatic Diseases PG - 1--8 VI - 37 IP - 1 4099 - http://ard.bmj.com/content/37/1/1.short 4100 - http://ard.bmj.com/content/37/1/1.full SO - Ann Rheum Dis1978 Feb 01; 37 AB - The effect of therapeutic concentrations of D-penicillamine, sodium aurothiomalate, and levamisole on in vitro neutrophil chemotaxis and random migration in normal subjects and patients with rheumatoid arthritis was studied. D-penicillamine produced no changes. Sodium aurothiomalate produced dose-related reductions in chemotaxis in normal subjects and in patients who had a good clinical response to gold therapy, while patients who had failed to respond to gold showed a minimal nondose dependent reduction. Levamisole produced dose-dependent stimulation of chemotaxis, a greater effect found with the patients cells. Neutrophil chemotaxis improved to normal values in most patients responding to several months of D-penicillamine treatment but showed an immediate and marked stimulation in patients treated with levamisole.