PT  - JOURNAL ARTICLE
AU  - Brooks, P M
AU  - Buchanan, W W
AU  - Grove, M
AU  - Downie, W W
TI  - Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study.
AID  - 10.1136/ard.35.4.339
DP  - 1976 Aug 01
TA  - Annals of the Rheumatic Diseases
PG  - 339--343
VI  - 35
IP  - 4
4099  - http://ard.bmj.com/content/35/4/339.short
4100  - http://ard.bmj.com/content/35/4/339.full
SO  - Ann Rheum Dis1976 Aug 01; 35
AB  - The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the patients associated with a more rapid clearance of prednisolone from plasma. It is considered that phenobarbitone induced the hepatic metabolism of prednisolone, effectively reducing the steady state plasma level and resulting in clinical relapse. A slight but significant improvement in the adrenocortical response to tetracosactrin (Synacthen) was noted after phenobarbitone therapy.