eLetters

322 e-Letters

  • A simple 'instrument' for memorizing the 11 features of axial spondyloarthritis (axSpA)
    Anand Malaviya
    Dear Editor,

    For the classification of axial spondyloarthritis (axSpA) Assessment of SpondyloArthritis international Society (ASAS) criteria are to be applied in patients with back pain of > 3 months and age at onset of back pain <45 years who have:
    (1) Sacroiliitis on imaging (definite sacroiliitis according to modified New York criteria OR active {acute}) inflammation on MRI highly suggestive of sacroiliitis assoc...

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  • HIGH SERUM IL-15 IS ASSOCIATED TO INCREASED LEVELS OF TOTAL RANKL. COMMENT ON AN ARTICLE BY KNEVEL ET AL.
    Isidoro Gonzalez-Alvaro
    Dear Editor,

    We have read with interest the article by Knevel et al, entitled “Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study” published on-line on March 22, 2012.1 The authors describe an elegant candidate gene study using four datasets of European rheumatoid arthritis (RA) patients with longitudinal radiological data, which let them conclude that genetic...

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  • Blocking IL-1 in SAPHO syndrome
    Matteo Colina

    Dear Editor,

    We read with great interest the article by Wendling et al. published online on January 4, 2012 in Annals of The Rheumatic Diseases, reporting a case series of SAPHO patients treated with anakinra (1). Some time ago, we firstly described a dysregulation of the P2X7 receptor-inflammasome axis in a patient with SAPHO syndrome successfully treated with anakinra, suggesting that interleukin-1 (IL-1) was very...

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  • Letter about the paper "Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study." by M Sebastianni.
    Sophie Blaise
    Dear Editor,

    We read with interest the paper of M Sebastianni et al about the predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis(1). The authors suggest that the CSURI score "can represent a feasible and reliable clinical tool in the routine evaluation of patients". However, we feel this report raises serious issues concerning the reproducibility of the methodology. When calculating the score, the num...

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  • Isn't age a factor?
    Matthew L Grove

    Dear Editor,

    Table 1 shows that PMR patients were significantly older than comparison subjects. Yet age wasn't included in the univariate or multivariate logistic regression models.

    A personal bugbear around the misdiagnosis of PMR is the misapplication of the label to relatively young patients without adequate clinical due diligence to exclude mimicking conditions. Since the incidence of PMR rises steep...

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  • Should we routinely check vitamin D and calcium levels before rituximab therapy?
    Peter M Wilding

    Dear Editor,

    The maintenance of serum calcium within normal limits is important to sustain life. In vitamin D deficiency calcium cannot adequately be absorbed by the intestinal mucosa. The lack of both of these important players in bone health and can bring about secondary hyperparathyroidism[1].

    The excess PTH, among other things, stimulates osteoclastogenesis[2] and liberates calcium from the skeleton t...

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  • Pattern analysis in vasculitides
    Laurent ARNAUD

    Dear Editor,

    We read with great interest the recent paper by Grayson et al., which compared patterns of arteriographic lesions in patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA).

    Using a similar methodology as in a previous paper by our group (2), Grayson et al. confirmed that arterial involvement is contiguous in the aorta and usually symmetric in paired branch vessels for TAK,...

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  • Direct and indirect effect of IL-17A on platelet aggregation
    Fulvio D'Acquisto

    Dear Editor,

    A recent report by Hot and colleagues investigated the possible link between the increased expression of IL-17 in rheumatoid diseases and the high incidence of cardiovascular disorders in patients suffering these pathologies.

    To address this point the authors used an elegant approach that combined in vitro cell functional studies with gene fingerprint analysis by microarray. Consistent with...

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  • Quantification of circulating endothelial progenitor cells in systemic sclerosis
    Jerome Avouac

    Dear Editor,

    We read with great interest the manuscript from Kuwana and coworkers related to the external validation of the EUSTAR recommendations on endothelial progenitor cells (EPCs)(1, 2). The side-by-side comparisons of methods for quantifying EPCs performed on 11 SSc patients and 11 age- matched controls showed a statistically significant correlation between EPC counts obtained by the MACS (enrichment of CD34+...

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  • Re:Confounding by indication invalidates most observational studies on side effects of glucocorticoids
    William G. Dixon

    Dear Editor,

    We thank the authors for their interest in our paper and extending the discussion about how we can best assess the safety of glucocorticoid therapy. Ongoing uncertainty about the safety of steroids - particularly at low doses - despite over sixty years of clinical experience illustrates this is not an easy challenge. Nonetheless, it is important to tackle given the continuing widespread use. We must mov...

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