eLetters

322 e-Letters

  • Comment on the article by Clowse, et al.
    Ryo Rokutanda

    Dear Editor,

    Clowse et al.[1] report that ferritin, oestradiol, and uric acid level at mid-gestation may predict preterm delivery in systemic lupus erythematosus (SLE) with mild-moderate disease activity. This is a well- done study, but we believe that the authors fail to fully address the effect of antiphospholipid antibodies. The author states that four patients tested positive for antiphospholipid antibodies....

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  • TNF antagonists and Shingles: Is Vaccination Advisable?
    Muhammad K Nisar

    Dear Editor,

    We read with interest the report by Galloway et al on the risk of skin and soft tissue infections (including shingles) in patients exposed to TNF antagonists from the BSRBR [1]. In the light of our recently published systematic literature review of the risk of shingles in rheumatoid arthritis (RA) patients, we would like to address several issues raised in the report [2]. The authors state that the inci...

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  • Step up therapy remains an appropriate option
    Duncan R Porter

    Dear Editor,

    I congratulate the research team from Rotterdam for the high quality study design of the tREACH study, but their conclusions are over-stated [1]. Their quotation of the literature is incomplete, referring to studies that have studied initial combination DMARDs plus corticosteroid (BeSt, FinRACo, COBRA) but excluding those studies that do not support their conclusions. There have been two previously publ...

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  • BAFF levels in association with response to TNFa antagonists; comment on the article by Genovese et al
    Athina Pyrpasopoulou

    Triantafyllou Areti, Pyrpasopoulou Athina, Anyfanti Panagiota, Balaska Ekaterini, Aslanidis Spyros, Douma Stella

    2nd Propedeutic Dept of Internal Medicine, Hippokration GH, Thessaloniki, Greece

    Dear Editor,

    We read with great interest the article by Genovese et al on the effect of the BAFF antagonist tabalumab in rheumatoid arthritis patients with inadequate response to TNFa blockade. The res...

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  • Improvement in Gout Management by Non-Rheumatologists Following Introduction of Guidelines
    Swan S Yeap

    Dear Editor,

    We read with interest the article by Doherty et al [1] where they lament suboptimal care of patients with gout, as the majority are managed by non-specialists. In 2005, we had surveyed non-rheumatologists on their practices regarding the management of gout [2]. Of the 128 respondents, 52.3% were general practitioners (GPs). A significant proportion of respondents were treating gout sub-optimally; 50% w...

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  • Needed number of events for logistic regression analysis
    Tomoyuki Kawada

    Dear Editor,

    I read with great interest the paper by van Sijl et al., (1) a 3-year longitudinal study by following patients with rheumatoid arthritis (RA) to know the effect of the estimated renal function on cardiovascular (CV) events. Out of 330 participants, 23 had CV event (7%). They mentioned the study limitation of low statistical power derived from small number of CV event and restriction of confounding va...

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  • How reliable is the diagnosis of very early rheumatoid arthritis in the multicentre real life prospective study as a predictor of remission?
    henning zeidler

    Dear Editor, Gremese et al. conclude from the real life prospective study performed in three early arthritis clinics that 12 weeks disease duration and an early intervention with DMARD represent the most significant opportunities to reach remission of RA. Moreover, it is supposed that vera early rheumatoid arthritis (VERA) represents a window of opportunity in terms of cost saving.

    A high level of confidence in t...

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  • Updated meta-analysis of non-melanoma skin cancer rates reported from prospective observational studies in patients treated with tumour necrosis factor inhibitors
    Xavier Mariette

    Dear Editor,

    Dear Editor,

    We recently published a meta-analysis of malignancy rates reported from prospective observational studies in patients treated with tumour necrosis factor inhibitors (TNF-I). [1] Whilst there was no increase in the rates of all-site malignancy or lymphoma, there was an increased risk of non-melanoma skin cancer (NMSC) (1.45, 95% CI 1.15 to 1.76).

    The skin cancer analysis incl...

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  • DMARDs combination or biological therapy in rheumatoid arthritis patients
    Carlos Abud-Mendoza

    Dear Editor,

    We read with interest the paper by De Jong PH et al.,(1) a single blinded clinical trial which reports that triple disease modifying antirheumatic drugs (DMARDs) induction therapy is better than methotrexate (MTX) monotherapy in early rheumatoid arthritis (RA).

    Our Hospital is located in San Luis Potosí (Mexico) and our cohort includes low income patients without any opportunities for biological th...

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  • Seasonal effects of first symptoms on short-term versus long-term outcome in early arthritis
    Maurizio Cutolo

    Dear Editor,

    We read with great interest the letter from de Rooy et al. published in the last issue of the Journal (1).

    By analyzing the conclusions of this investigation in connection to another recent report about the real onset of arthritis symptoms during winter or spring and related more radiographic joint damage after 1 year, it seems that the authors found slightly different results that need some...

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