eLetters

322 e-Letters

  • The Reasons of Higher NT-proBNP Depend On Very Different Conditions
    Mehmet Aydogan

    Dear Editor,

    We read the article ''N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) and mortality risk in early inflammatory polyarthritis (IP): results from the Norfolk Arthritis Registry (NOAR).'' by Mirjafari et al with interest(1). The authors aimed to measure serum NT-pro-BNP levels in a large, well characterised inception cohort of patients with early IP and to examine baseline association of NT-pr...

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  • Anaemia to predict radiographic progression in Rheumatoid Arthritis
    Hanna W. van Steenbergen

    Dear Editor,

    The severity of rheumatoid arthritis (RA) is highly variable between patients and currently known risk factors explain only part of this variance.(1) Much research is dedicated to identify additional new risk factors. Such factors may shed light on the processes underlying progression of RA and many risk factors together may enable risk stratification and individualized treatment of RA.

    With...

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  • PGI2-induced Th17 cells differentiation in connective tissue disease: a comment
    He Jianguo

    Dear Editor

    We read with interest the study conducted by Truchetet and colleagues on the regulation of PGI2 in Th17 cells differentiation in systemic sclerosis (SSc). Actually, previous in vitro studies have found that synthetic PGI2 enhanced Th17 cells differentiation1. Zhou et al2 has also demonstrated that PGI2 induced Th17 cells differentiation through modulating the ratio of IL-23/IL-12 in a mouse model of experim...

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  • Response to comments by Clockaerts and colleagues
    Daniel L. Riddle

    Dear Editor,

    We thank Clockaerts and colleagues for their thoughtful commentary on our paper and will address a number of their comments. They expressed concern regarding lack of verification of our data related to statin use, duration of use, and dosage, and indicated these data were based on self- report. While we acknowledged in our paper[1] that we did not have dosage data, the verification was that participants...

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  • Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial
    Claire-Louise Murphy

    Dear Editor,

    We read with interest the paper regarding Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo- controlled trial. We note the exclusion criteria included secondary knee osteoarthritis. On review of the results section it appears that many of the patients both the randomised and the intention to treat groups e.g. the stronti...

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  • Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralizing agents in chronic inflammatory diseases: a real issue, a clinical perspective. Comment on the article of Vincent et al.
    Alfons A den Broeder

    Dear Editor,

    Vincent et al present a thorough review of available clinical research on antidrug antibodies to tumour necrosis factor blocking agents (1). We agree to a large extent with their interpretation of the data with regard to pathofysiology, assay characteristics and variation in drug and antidrug antibody serum levels. However, the conclusion that measurement of (anti)drug levels should therefore be used f...

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  • Erdheim-Chester disease
    Albert Selva-O'Callaghan

    Dear Editor,

    We read with interest the excellent study published by Cavalli et al.1 in ARD and would like to voice some considerations. Although heterogeneity is the rule in the clinical presentation of patients with Erdheim-Chester disease (ECD), some manifestations should be regarded as diagnostic triggers of this condition. The presence of unexpected interstitial lung disease on chest radiography, a coated aorta...

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  • Which ultrasound method has the upper hand in the follow-up of the patients with recurrent carpal tunnel syndrome?
    Antonios Kerasnoudis

    Dear Editor,

    I read with great interest the study of different diagnostic ultrasound measures of median nerve volume in patients with carpal tunnel syndrome (CTS) by Dejaco et al. (1). It is of great value, in my opinion, that this study succeeded not only in highlighting the diagnostic value and good reliability of ultrasound determination of median nerve cross sectional area (CSA) in patients with suspected CT...

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  • Herpes zoster infection risk in patients with rheumatoid arthritis on tumor necrosis factor inhibitors Prabha Ranganathan MD, MS
    PRABHA RANGANATHAN

    Dear Editor,

    We read with interest the study conducted by Galloway and colleagues on the risk of skin and soft tissue infections (SSTI) and herpes zoster (HZ) in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF) antagonists versus non-biologic disease-modifying anti-rheumatic drugs (nbDMARDs). (1) This study highlights the occurrence of common infections such as SSTI and more unco...

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  • Are IL-10+ regulatory Th17 cells implicated in the sustained response to glucocorticoid treatment in patients with Giant Cell Arteritis? Comment on the paper of Espigol-Frigole et al.
    Maxime Samson
    Dear editor,

    We have read with interest the recently published paper of Espigol-Frigole et al. 1 in which the authors confirmed that IL-17 is highly expressed in giant cell arteritis (GCA) lesions.1-3 They also demonstrated for the first time that IL-17 expression in temporal artery biopsies (TAB) was correlated with a better outcome. Among other interesting results, the identification of Foxp3+IL-17+ T cells by confocal micro...

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