I read with immense interest the e-letter on the analgesic effect of
pamidronate.In fact I have been observing this effect with alendronate for
past couple of years. When I prescribe weeky alendronate for my patients
who also have rheumatoid arthritis, they come back requesting for the
weekly dose to be prescribed daily. The symptom relief however lasts only
for the day the dose is administered. In...
I read with immense interest the e-letter on the analgesic effect of
pamidronate.In fact I have been observing this effect with alendronate for
past couple of years. When I prescribe weeky alendronate for my patients
who also have rheumatoid arthritis, they come back requesting for the
weekly dose to be prescribed daily. The symptom relief however lasts only
for the day the dose is administered. In other words even though the effect
of weekly alendronate on osteoporosis may last a whole week, the pain
relief as well as a feeling of well being and improvement in appetite
lasts only for the day it is given.
I am wondering why, in this day and age, researchers into the long
term effects/links of infections and the possible connection with
potentially devastating conditions do not use PCR testing for the
identification of these infecting or trigger organisms?
My understanding is that PCR testing is far more sensitive than indirect
methods of detecting the body's response to the bug concerned.
I am wondering why, in this day and age, researchers into the long
term effects/links of infections and the possible connection with
potentially devastating conditions do not use PCR testing for the
identification of these infecting or trigger organisms?
My understanding is that PCR testing is far more sensitive than indirect
methods of detecting the body's response to the bug concerned.
The surveys were conducted in 1970s. At that time the majority of
Finns drank traditional boiled coffee. The use of decaffeinated coffee was
exceptional. In the Mini-Finland Health Survey, there was a negative
correlation between daily cups of tea and coffee (age and sex adjusted
partial r= -0.30, p...
The surveys were conducted in 1970s. At that time the majority of
Finns drank traditional boiled coffee. The use of decaffeinated coffee was
exceptional. In the Mini-Finland Health Survey, there was a negative
correlation between daily cups of tea and coffee (age and sex adjusted
partial r= -0.30, p<_0.001. however="however" tea="0.91," consumption="consumption" showed="showed" no="no" association="association" with="with" the="the" presence="presence" of="of" rheumatoid="rheumatoid" factor="factor" age="age" and="and" sex="sex" adjusted="adjusted" odds="odds" ratio="ratio" per="per" one="one" cup="cup" _95="_95" confidence="confidence" interval="0.73-1.13)" did="did" not="not" confound="confound" results="results" we="we" reported.p="reported.p"/>Unfortunately we had no
information on the consumption of colas, but according to indirect
information on sales of cola beverages the contribution of caffeine from
this source was minimal in Finns at that time.
Markku Heliövaara
Kimmo Aho
Paul Knekt
Antti Reunanen
Arpo Aromaa
National Public Health Institute, Helsinki, Finland
Olli Impivaara
Social Insurance Institution, Research and Development Centre, Turku, Finland
Correspondence to: Dr Markku Heliövaara, National Public Health
Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
This potentially valuable information about a relationship between
coffee consumption and the presence of the rhematoid factor is difficult
to evaluate because of a lack of clarity in definitions. What is meant by
"coffee"? Is coffee, caffeinated or decaffeinated? This is an obvious
distinction that readers need to consider these findings.
Also, it would
have been interesting to have information ab...
This potentially valuable information about a relationship between
coffee consumption and the presence of the rhematoid factor is difficult
to evaluate because of a lack of clarity in definitions. What is meant by
"coffee"? Is coffee, caffeinated or decaffeinated? This is an obvious
distinction that readers need to consider these findings.
Also, it would
have been interesting to have information about other beverage
consumption, such as colas and/or teas which may or may not have affected
or clarified the results which, currently, have no theoretical
underpinnings. However, the information is an exciting start to
understanding factors that contribute to this disabling and prevalent
illness.
Dear Editor,
I read with immense interest the e-letter on the analgesic effect of pamidronate.In fact I have been observing this effect with alendronate for past couple of years. When I prescribe weeky alendronate for my patients who also have rheumatoid arthritis, they come back requesting for the weekly dose to be prescribed daily. The symptom relief however lasts only for the day the dose is administered. In...
I am wondering why, in this day and age, researchers into the long term effects/links of infections and the possible connection with potentially devastating conditions do not use PCR testing for the identification of these infecting or trigger organisms? My understanding is that PCR testing is far more sensitive than indirect methods of detecting the body's response to the bug concerned.
I would be inte...
Dear Editor:
The surveys were conducted in 1970s. At that time the majority of Finns drank traditional boiled coffee. The use of decaffeinated coffee was exceptional. In the Mini-Finland Health Survey, there was a negative correlation between daily cups of tea and coffee (age and sex adjusted partial r= -0.30, p...
This potentially valuable information about a relationship between coffee consumption and the presence of the rhematoid factor is difficult to evaluate because of a lack of clarity in definitions. What is meant by "coffee"? Is coffee, caffeinated or decaffeinated? This is an obvious distinction that readers need to consider these findings.
Also, it would have been interesting to have information ab...
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