93 e-Letters

published between 2007 and 2010

  • The lipids after one year therapy with infliximab and etanercept in woman with rheumatoid arthritis
    Maciej Lewicki

    Dear Editor,

    We read with the great interest the paper by Garces et al. Anti-tumour necrosis factor agents and lipid profile: a class effect? [1] In this study the investigators showed the different effect on lipid profile between infliximab and etanercept in patient with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA). We would like to present the similar study in RA patients treate...

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  • Association between quantitative anti-CCP levels and HLA-DR4 expression in rheumatoid arthritis
    Zoltán Szekanecz

    Sir, In their study, Lee et al (1) studied possible associations between anti-CCP titers and several markers of disease pathogenesis and activity of rheumatoid arthritis (RA)including the presence of erosions, CRP, ESR, disease duration and history of smoking. They report a significant association between anti-CCP titers and history of smoking. Authors are right that the vast majority of anti-CCP studies only deal with the p...

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  • Comment on article by Lanternier
    Clive A Kelly

    Dear Sir

    We write in response to a recent letter in the Annals describing a low vaccination rate among adults with systemic inflammatory disease [1].
    Lanternier et al reported vaccination rates of 57% among patients with rheumatoid arthritis (RA) and found that the biggest barrier to vaccination was the failure of medical staff to recommend it! The authors conclude that all such patients should be tar...

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  • irreversible hodgkin's lymphoma in 2 patients treated with methotrexate
    vladimir gotlieb

    Dear Editor

    As it was mentioned in multiple manuscripts related to the topic several different possibilities could explain why the patients develop enlarged lymph nodes. Among those are indolent lymphomas, lymphatic hyperplasia and aggressive lymphomas, including both Hodgkin’s lymphoma and large B-cell lymphoma, which are usually associated with Epstein-Barr infection, The other possibilities include Castelman’s D...

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  • Vitamin D link to pain: SF-12 responses and PTH status
    Kerrie M Sanders

    Dear Editor,

    We were interested in the finding by Atherton and colleagues of an association between current vitamin D status and chronic widespread pain (CWP)[1]. The authors conclude: “Follow-up studies are needed to evaluate whether higher vitamin D intake might have beneficial effects on CWP risk”.

    We are completing a large randomised, placebo-controlled trial on vitamin D and can contribute preliminary re...

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  • Nailfold capillaroscopy in scleroderma
    Pieternella M. Houtman

    Dear Editor,

    I read with great interest the article by Sulli et al[1] on scoring the nailfold microvascular changes during the capillaroscopic analysis in systemic sclerosis patients. The capillary abnormalities occurring in scleroderma-spectrum disorders were described by Maricq et al over 30 years ago and include enlarged capillary loops, areas of avascularity and haemorrhages. Since than many cross-sectional studies...

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  • On the feasability of formal musculoskeletal ultrasonography training for rheumatologists
    Feride Gogus

    Dear Sir,

    Over the past decade musculoskeletal ultrasound (MSU) has recognised a growing interest among rheumatologists. Cumulating evidence demonstrating the benefit of performing MSU for both patients and rheumatologists has further increased the interest in this imaging modality (1,2). However, although MSU is a fast expanding area in rheumatology, there is still not much information on crucial issues like training...

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  • Potential confounding effects of smoking on Body Mass Index in Rheumatoid Arthritis
    Jenny H Scott

    Dear Editor,

    We read with interest the article by van der Helm, which explores the relationship between Body Mass Index (BMI) and radiological damage in early rheumatoid arthritis (RA). We were particularly interested in the finding that patients with baseline BMI lesser than 25 developed more erosive disease during follow-up than those with increased BMIs. This association was only observed in those patients who were...

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  • Anti-TNF-alpha therapy, statins and response to influenza vaccination: a word of caution.
    Mark R Goldstein, MD

    Dear Editor,

    We read the interesting paper of Dr. Gelinck and associates on the effect of anti-tumour necrosis factor-alpha (anti-TNF-á) therapy on the antibody response to influenza vaccination [1]. Although there was a modest impairment of the antibody response to the vaccination, the proportion of patients achieving a protective titer was not significantly diminished. However, we have oncerns on generalizing these res...

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  • Re: Identification of Pneumocystis colonization in patients treated with Infliximab
    Tsutomu Takeuchi

    Dear Editor,

    We thank Dr Wissmann for the eLetter concerning Pneumocystis jiroveci pneumonia (PCP) to our article, "Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis. Ann Rheum Dis 2008;67:189-194.

    We reported that PCP developed in 22 patients among 5,000 patients with RA treated with infliximab. The organism of Pneumocysits jiroveci was not i...

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