131 e-Letters

published between 2005 and 2008

  • PHA concentration in IGRA assays
    Christopher J Granger

    Dear Editor, In the article by Matulis et al, published online on 20 July 2007 the authors state in their discussion that “Compared with the ELISA test used in our study the IFN-gamma ELISPOT test was previously reported to have lower rates of indeterminate results (1). These differences may, among other reasons, be explained by differences in the concentrations of the mitogen PHA between the two test systems”. Can the authors...

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  • Real characterization and follow up of histiocytosis bone lesions by ultrasonography
    Mahamoud M Gabal

    Dear Editor, plain X-ray films will demonstrate the bony defect and its margin whether it is sclerotic or not. In that lesions due to excessive bone marrow infiltration and soft tissue formation , the soft tissue formed is directly proportional to the bone marrow infiltration and disease activitynot to the size of the bone defect. The accurate parameter to follow up the bone marrow infiltration or recovery is to follow up t...

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  • Characteristics of patients with rheumatoid arthritis in Hungary: comparison with the QUEST-RA study
    Marta Pentek

    Dear Editor, Sokka et al reported results of a survey of rheumatoid arthritis (RA) patients from 15 countries in 2005-2006, the QUEST-RA study.[1] A similar cross sectional survey was performed in 2004 in Hungary by rheumatologists involving 257 consecutive patients with RA attending routine visits to 6 hospital based outpatient rheumatology centres. Detailed description of the study and certain disease parameters has been publ...

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  • Comment on “G. Schett et al., Tumour necrosis factor blockers and structural remodelling in ..
    Frank P Luyten

    Dear Editor, we read with interest the editorial by Schett et al. on structural remodeling in ankylosing spondylitis. [1] We acknowledge the effort to highlight potential differences between ankylosing spondylitis and rheumatoid arthritis but would like to underline a number of critical issues. Most importantly, the authors did not distinguish the process of new cartilage and bone formation at the enthesis as seen in the di...

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  • Thank you
    Lia T. Umikashvili

    Dear Editor, this is the most up-to-dated, complete, holistic and informative article on AOSD existed contemporaneously.

    My only addition/suggestion would be to indicate suggested average duration of treatment (for steroids and immunosuppressive drugs) when symptoms are controlled. What it should be an average duration of giving for example methotrexate or plaqueline when laboratory tests are within the norm, symptoms...

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  • About “Scleroderma lung study"
    Paola Caramaschi

    Dear Sir,

    We have read the interesting paper of Clements PJ et al (1) as well as their previous article “Cyclophosphamide versus placebo in scleroderma lung disease” (2).

    We think the Authors should give information about the autoantibody status of the patients; the recent analysis of the very large EUSTAR cohort of scleroderma cases demonstrated that autoantibody specificity is more closely related to or...

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  • Henoch Schönlein Purpura is not associated with mutations in Mevalonate Kinase gene.
    Alessandra Pontillo

    Dear Editor,

    The issue that mutations in genes responsible for autoinflammatory syndromes could explain also some inflammatory or rheumatological disorders has been raised in recent researches. In particular, Mevalonate Kinase Deficiency (MKD) can occasionally overlap clinically and genetically with Behcet's disease. A clinical overlap could be observed also between episodes of MKD and Henoch Schönlein Purpura (HSP):...

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  • DAS28-CRP should be evaluated using different criteria from that for DAS28-ESR
    José M. Martín Santos

    Dear Editor,

    We have read with interest the article recently published by Matsui et al (1). They study a large cohort of patients with rheumatoid arthritisfrom 33 hospitals in Japan and conclude that the modified Disease Activity Score including 28-joint count and using C-reactive protein (DAS28-CRP) gives mean values lower than the same index using ESR (DAS28-ESR). They find a mean difference of 0.72 and state that DAS...

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  • Comments on the Reassessment of the 2006 revised antiphospholipid syndriome classification criteria
    Antonio R. Cabral

    Dear Editor, The recent retrospective study by Kaul et al(1) on the assessment of the 2006 revised classification criteria for definite antiphospholipid syndrome (2) sets the ground for at least three issues. a) The inclusion of “non-criteria aPL features” in the revised APS criteria is indeed a step forward, but it appears that it requires revaluation, particularly with regards to the addition of thrombocytopenia as a dist...

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  • About the fourth EULAR recommendation for hand osteoarthritis.
    Romain J Forestier

    Dear Editor, W Zhang and al. in their fourth recommendation for hand osteoarthritis consider that their proposition is based on expert opinion alone. In France, and probably other European country, spa therapy (with hot mud, water or cloud) is often used for treating hand osteoarthritis. A French spa centre supported two randomised clinical trial: One showed positive and equivalent effect between two different types of mud...

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