eLetters

322 e-Letters

  • Impact of gender on outcomes in ankylosing spondylitis
    Ernst Feldtkeller

    Dear Editor,

    We read with interest the article on the impact of gender on outcomes in ankylosing spondylitis [1]. In their analysis of four controlled clinical trials, the authors found a higher burden of ankylosing spondylitis (AS) in female patients and less improvement in outcome measures compared with men, "despite women having a later disease onset and shorter disease duration". They conclude that the mechanism...

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  • Are steroids required for therapy induction and relapses in lupus nephritis?
    Carlos Abud-Mendoza

    Dear Editor,

    “A finger in the wound” is put by Condon et al. in their very interesting paper treating severe lupus nephritis with rituximab and mycophenolate, additionally to i.v. methyl-prednisolone, but not long-term oral steroids, achieving a good clinical response in most patients. 1

    Rheumatologists and nephrologists have the notion that glucocorticoids are the cornerstone for the treatment of autoimmune disea...

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  • Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomized, placebo-controlled trial
    Jean-Yves Reginster

    Dear Editor,

    We would like to reply to the recent letter by Murphy et al(1) regarding the possible influence of obesity and weight changes on the results of the SEKOIA trial of the efficacy and safety of strontium ranelate in knee osteoarthritis.2 Obesity and overweight are recognized risk factors for osteoarthritis,3 and so it is essential to include such patients in studies of potential treatments, since they are...

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  • Is early remission associated with improved survival or is arthritis persistency associated with increased mortality in early arthritis?- comparisons with the general population
    Jessica AB van Nies

    Dear editor,

    With interest we read the article of Sciré et al.,(1) evaluating the association between remission and mortality in patients with inflammatory polyarthritis (IP). This study shows that patients achieving remission early in the disease course, have an improved survival rate compared to patients never achieving remission. Based on this observation the authors conclude that achieving remission early in t...

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  • INTERLEUKIN-6 ACTS LOCALLY ON THE GROWTH PLATE TO IMPAIR BONE GROWTH
    PF Fernandez-Vojvodich

    Dear editor,

    A recent clinical study in mothers with rheumatoid arthritis (RA) published in this journal, reported that high maternal serum levels of interleukin-6 (IL-6) is associated with low birth weight deliveries1. Low birth weight in turn is associated with impaired growth during childhood2. Interestingly, overexpression of IL-6 leads to reduced bone growth in mice3. Although the systemic effects of IL-6...

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  • Usefulness of ultrasonography in the diagnosis of gout: a meta-analysis
    Sylvain Mathieu

    Dear Editor,

    In an article published in Annals of the Rheumatic Diseases, Chowalloor et al. suggested, based on a literature review, that ultrasonography (US) is a promising tool which could be used in the diagnosis and management of gout [1]. In this letter, we wish to add further data to the Chowalloor et al. conclusion. We have performed a meta-analysis (up to July 2012) to investigate the frequency of ultrasonograph...

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  • Strontium and cardiovascular events
    Mark J Bolland

    Dear Editor,

    In the report of their trial of strontium ranelate in knee osteoarthritis, Reginster and colleagues state that "Strontium ranelate was well tolerated" and that "The safety profile of strontium ranelate was satisfactory, in line with knowledge of this agent" (1). However, contemporaneously, the European Medicines Agency recommended that the use of strontium ranelate be restricted because it increased the r...

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  • Systemic literature review of the performance of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis. Good news of debatable significance
    henning zeidler

    Dear Editor,

    Radner and colleagues report a systematic literature search analysing the numerous articles and conference proceedings which examined the performance of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis (RA) (1). The comprehensive evaluation identified if the 2010 criteria were correctly applied as suggested in the original publication, explored the performance of the criteria according...

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  • Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis
    Harry Sprot

    Dear Editor,

    Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis I read with interest this paper by Van Spil et al examining further the osteoarthritis(OA) biomarker CTX-II (C-terminal telopeptide of type II collagen) and note the suspicions of the authors tying this marker to bone metabolism[1]. High correlation wi...

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  • Patients with non-Jo-1 anti-RNA-synthetase autoantibodies have worse survival than Jo-1 positive patients
    Baptiste Hervier
    Dear Editor,

    We read with interest the manuscript by Aggarwal et al. entitled “Patients with non-Jo-1 anti-RNA-synthetase autoantibodies have worse survival than Jo-1 positive patients” 1. This large cohort study provides important information on outcomes for patients with antisynthetase syndrome (ASS), based on the specificity of the anti-RNA-synthetase autoantibody subtypes. Interestingly, the authors decided to include patie...

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