eLetters

322 e-Letters

  • The efficacy of double blind foreign language research
    Jim Leahy

    Dear Editor

    This critique will be brief and applicable to much of our research today, por desgracia:

    • Fifty six experimental research candidates seems anecdotal at best and misleading at worst.
    • Who are these people? Are they from Greece or Norway, or both?
    • The placebo effect seems less than sanguine in 2003. More folks seem capable of monitoring themselves and using...
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  • Authors' reply
    Mikko M Haara

    Dear Editor

    We are grateful for the thoughtful comments by Grindulis et al.[1] concerning osteoarthritis (OA) as a predictor of cardiovascular mortality.[2] We agree that our results could have been presented in more detail. A priori, however, we had focused our comprehensive study on the prevalence of finger OA, on its risk determinants and on its association with total mortality. Interestingly, we ob...

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  • Asymptomatic diffuse pulmonary embolism caused by acrylic cement : an unusual complication of percut
    Grados Franck

    Dear Editor

    We read with interest the letter by Bernhard et al.[1] Pulmonary embolism caused by polymethylmethacrylate (PMMA) is not an exceptional complication of percutaneous vertebroplasty for the treatment of osteoporotic vertebral fractures. It occured in one patient (2.9%) in our study [2] (34 vertebroplasties), in two patients (4.3%) in the study by Jensen [3] et al. (47 vertebroplasties) and i...

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  • Osteoarthritis and cardiovascular death
    Karl A Grindulis

    Dear Editor

    Haara et al. recently published a study assessing epidemiological aspects of osteoarthritis (OA) in Finland.[1] A finding of interest was their identification of OA (in any finger joint) as a predictor of cardiovascular death among men, with the authors suggesting an undetermined metabolic factor as a mechanism. It may be that the disability conferred by OA in the lower limbs delays presenta...

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  • HCV infection and rheumatoid arthritis
    Giuseppe Provenzano

    Dear Editor

    Maillefert and colleagues have reported an interesting study concerning the possible relationship between hepatitis C virus (HCV)infection and rheumatoid arthritis (RA).[1] They found a 0.65 % prevalence of HCV infection in 309 patients with RA, which is similar to that reported in the general French population.[2] They concluded that HCV infection can not be implicated in the pathogenesis of RA. HCV in...

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  • HLA-DR typing before aluminic vaccines to prevent macrophagic myofasciitis
    Jean Roudier

    Dear Editor

    Hepatitis B vaccination has been reported to trigger autoimmune conditions on the appropriate genetic background. Macrophagic myofasciitis (MMF) is a recently described muscle disease that seems to be triggered by aluminic vaccines (hepatitis B and tetanus toxoid). We recently observed an interesting case of identical twins who both developed MMF after hepatitis B vaccination. This observation suggested the...

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  • Efficacy and safety of cyclosporine-A versus parenteral gold in early rheumatoid arthritis patients
    Alexandros A. Drosos

    Dear Editor

    We read with interest the article by Dr Kvien and colleagues concerning cyclosporine–A (CsA) versus parenteral gold salts (PGS) in early rheumatoid arthritis (RA).[1] The authors concluded that both drugs had similar results on radiological progression of the disease, while CsA was associated with severe side effects especially hypertension and renal function impairment. We would like to make some comme...

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  • Infilximab in Ocular Behçet's Disease
    Imad Uthman

    Dear Editor

    We read with great interest the letter of Triolo et al[1]. In the discussion section of the article the authors mentioned that this is the first report of the treatment of ocular BD with anticytokine specific treatment.

    In July 2001, Sfikakis et al.[2] reported on a series of five patients with relapsing Behçet's panuveitis, treated with a single infusion of infliximab at the immed...

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  • Symptom relief with biphosphonates in arthritis.
    Sandeep Saluja

    Dear Editor,

    I read with immense interest the e-letter on the analgesic effect of pamidronate.In fact I have been observing this effect with alendronate for past couple of years. When I prescribe weeky alendronate for my patients who also have rheumatoid arthritis, they come back requesting for the weekly dose to be prescribed daily. The symptom relief however lasts only for the day the dose is administered. In...

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  • Testing
    P Stowell
    Dear Editor

    I am wondering why, in this day and age, researchers into the long term effects/links of infections and the possible connection with potentially devastating conditions do not use PCR testing for the identification of these infecting or trigger organisms? My understanding is that PCR testing is far more sensitive than indirect methods of detecting the body's response to the bug concerned.

    I would be inte...

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