131 e-Letters

published between 2005 and 2008

  • Comment on Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthrit
    Zsolt Balogh

    Dear Editor,

    We read with expectations the study on cytokine signatures in patients with juvenile idiopathic arthritis (JIA) [1]. The widespread investigation of cytokines and chemokines, the smart and spectacular presentation of the results (especially Fig. 2.) are impressive. Even so, we must make a remark that the alignment of the patients has not been done the most fortunate way.

    As the authors state,...

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  • Sleep apnea - the missing gout comorbidity
    Burton Abrams

    Dear Editor, Even though the data may be difficult to obtain, it is important that sleep apnea be identified as a gout comorbidity. It actually is a causal factor for gout, and it is known to be strongly associated with all the other gout comorbidities listed in the above article. The hypoxic episodes of sleep apnea have two effects which can lead to a gout attack in short order. The first effect is the catabolic process initi...

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  • clinical endpoints in RA RCTs
    Maarten Boers

    Dear Editor, Verstappen et al are to be congratulated on their 'CAMERA' strategy trial. However, they have chosen not to report the results expressed in the Disease Activity Score (DAS or DAS28). In addition, the international RA core set agreed to in 1992 was not fully applied because physician global assessment was not measured. This is a pity because it precludes calculation of ACR reponse. The lack of both DAS and ACR re...

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  • What is the best DMARD agent for refractory FMF?
    Daniel G. Arkfeld

    Dear Editor, It is with great interest that I read the article "Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra" by Kuijk et al. Previously, our group reported on the successful treatment of FMF with secondary AA amyloid with the monoclonal anti-TNF agent Infliximab(reference 1). In this case, there was an additional benefit of complete resolution of proteinuria as well as resol...

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  • Long-term effects of etanercept treatment on lipid profile in patients with rheumatoid arthritis
    Bruno Seriolo

    Dear Editor, We have read with great interest the article by Peters et al. concerning the changes on lipid profile during infliximab and corticosteroid treatment in patients with rheumatoid arthritis (RA) (1). Recently, we performed a similar longitudinal study over time using a different TNF blocker – namely etanercept. In this prospective study 22 RA female patients were analyzed. Patients received during the study etan...

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  • Anti-TNFalpha treatment decreases procoagulant activity in patients with rheumatoid arthritis
    Piotr Gluszko

    Dear Editor,

    In their interesting review, Dixon W.G. and Symmons D.P.M (1) discuss the role of TNF alpha and other factors, which may contribute to the increased cardiovascular morbidity in patients with rheumatoid arthritis (RA). The Authors support a hypothesis that TNF alpha blockade may reduce development of atherosclerosis in RA.

    There is also a growing body of evidence that TNF alpha and other inflammatory...

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  • Response to Hjardem Elisabeth, et al article Ann Rheum Dis 2007; 66: 1184-1189
    Paul Emery

    To the editor,

    We read with interest the article by Hjardem E et al which reported the experiences of switching between TNF-antagonists from the Danish patient registry, DANIBO. We would like to draw the authors’ attention to data published from our group 2 years ago which both highlights some aspects relevant to the current report and which provides some insights into the mechanisms involved. Non-response is seen...

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  • Is monoarthritis of the knee really a paraneoplastic syndrome?
    John P. Livoni MD, MPH

    Dear Editor,

    This is a response to the article by Cantini et al suggesting that monoarthritis of the knee may herald non small-cell lung cancer. The authors found that 1.7% of patients with monoarthritis of the knee were found to have non-small-cell lung cancer. All of their patients with lungcancer were middle-aged heavy smokers. I would like to point out that a number of studies (1,2) have measured the prevalence of...

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  • Treatment of PAH associated with connective tissue disease
    Omar A. Minai

    Dear Editor, I read with interest the manuscript, by Girgis et al (1) on the role of sitaxsentan in the treatment of patients with pulmonary arterial hypertension associated with connective tissue diseases. The main conclusion is that sitaxsentan, a selective endothelin-A receptor antagonist, produced a significant improvement in six-minute walk distance, functional class, and quality of life in this group of patients.

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  • Tapering of steroids in Synthetase syndrome
    Able Lawrence

    Dear Editor, It was fascinating to read the letter on the use of Rituximab in synthetase syndrome. We taper steroids only gradually in patients with dermatomyositis to prevent relapse and more so in patients with synthetase syndrome in whom we usually start methotrexate from the beginning. The tapering schedule of steroids in the index patient which came down to 10mg in 3 months seems to be overly rapid from our experience. W...

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