eLetters

322 e-Letters

  • NSAIDs, including coxibs, probably do more harm than good, and paracetamol is ineffective for hip OA
    Jan M. Bjordal

    Dear Editor,

    New EULAR treatment guidelines in hip osteoarthritis were recently reviewed [1]. The recommendations are allegedly based on top level scientific (grade 1a) data, and advocate the use of paracetamol (US: acetaminophen) and non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase 2 inhibitors (coxibs), in osteoarthritis of the hip. We interpret the underlying data differently...

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  • Therapeutic potential of statins in rheumatic diseases
    Przemyslaw J. Kotyla

    Dear Editor,

    We read with a great interest article by McInnes and colleagues [1] concerning the beneficial properties of statins in patients with rheumatoid arthritis.

    HMG-CoA reductase inhibitors are widely used compounds introduced primarily as effective cholesterol lowering agents. With time, it has been recognised that effects of statins go far beyond only lipid lowering properties and nowadays they a...

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  • Should patients with medium risk of disease progression really be avoided in clinical trials?
    Jane S Angwin

    Dear Editor,

    Patient selection can affect required sample sizes and outcomes in randomised clinical trials and the optimal selection may depend on how the tested drug differentially affects patients. Bruynesteyn K et al. [1,2] have investigated these effects in rheumatoid arthritis based on an outcome measure of radiological damage progression.

    An absolute reduction (AR) drug which reduces the expe...

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  • "In Response to: Autoantibodies and thrombophilia in RA: TNF alpha and TNF alpha blockers-June 2004
    Alan M Mendelsohn

    Dear Editor,

    There has been growing interest in studies evaluating the effects of various disease modifying agents on endothelial dysfunction in patients with rheumatoid arthritis due to the predictive value of such properties on endothelial function on increased or decreased risk of cardiovascular events. We, therefore, read with great interest the article by Doctors Ferraciolo and Gremese in the June 2004 issue...

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  • Anakinra in the treatment of refractory adult onset Still’s disease
    Pierantonio Ostuni

    Dear Editor,

    We thank Dr Godinho and his co-authors for their report about usefulness of anakinra in the treatment of refractory adult onset Still’s disease (AOSD).

    Not all the patients with AOSD have a similar disease course: 4 different disease patterns (monocyclic systemic, monocyclic chronic articular, polycyclic systemic and polycyclic chronic articular) have been described [1]. On the other hand, c...

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  • E148Q MEFV sequence variation and familial Mediterranean fever
    Serge Amselem

    Dear Editor,

    We read with great interest the article by Topaloglu et al (Sep. 30 issue) [1] on the implication of the E148Q sequence variation in familial Mediterranean fever (FMF). In our opinion, the best interpretation of this study is not that E148Q is a disease-causing MEFV mutation, but, rather, that this sequence variation is not involved in FMF, or more precisely that the E148Q allele is not impli...

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  • Caution: under-powering a study can lead to overstated conclusions
    Anne-Maree Keenan

    Dear Editor,

    We wish to comment on the conclusions of a study recently published in Annals: A randomized controlled trial of intra-articular injection of the carpometacarpal joint of the thumb in osteoarthritis (Ann Rheum Dis 2004: 63:1260-1263).

    This study was designed as a randomized control trial, which was powered to detect a difference "between the placebo and steroid injection which was likely t...

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  • Arterial stiffness is increased in rheumatoid arthritis!
    Rainer Klocke

    Dear Editor,

    We thank Dr Chirinos for his interest in our article and appreciate his comments [1].

    We would disagree, however, with his suggestion that paired t-test is only appropriately used to analyze repeated measurements before and after an intervention in a single sample population. In our study the statistical analysis by a paired t-test was decided before data collection and based on the study d...

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  • Inappropriate use of bilateral measurements and correlations.
    Ole Rintek Madsen

    Dear Editor,

    In the paper by Schmidt et al, measurements of the left and right extremities of the same subjects seem to have been pooled to calculate standard reference values for musculoskeletal ultrasonography [1]. However, it is common knowledge that right and left measurements are tied and should not be mixed in order to get a larger “study sample”.

    In the same paper, correlations have been...

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  • Letter to Editor -- Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis
    Dennis S.C. Lam

    Dear Editor,

    We read with great interest the article by Allanore et al, and commend on their efforts in studying this important issue[1]. We would be most grateful if the authors can help to clarify a few points.

    Mean Deviation (MD) is the average of the numbers on the total deviation plot with each value weighted according to the magnitude of the normal range at that point. It signifies the over...

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