eLetters

322 e-Letters

  • Rheumatological presentations of paraneoplastic disease
    Holly Piper

    Dear Editor,

    We read with interest the case report by Denschlag et al. [1]. In addition, von Lilienfield-Toal et al. also recently described the presentation of adult onset Still’s disease associated with occult breast malignancy [2]. These case reports remind us that rheumatic symptoms may precede the diagnosis of an underlying neoplasm. We recently observed an atypical presentation of scleroderma associated wit...

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  • Experience versus Evidence
    Sidha S Sambandan

    Dear Editor,

    Over quarter of a century of experience with injecting steroids has led me to believe in the value of steroid injections for OA of small and large joints. I have used Depot-Medrone with lidocaine for the CMC Joint, especially in the elderly who have disabling CMC joint OA, leading to inability to lift a pot of Tea, an extremely important activity of daily living for the elderly at least in UK! Many...

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  • Cervical complications of rheumatoid arthritis
    Djurdja Babic-Naglic

    Dear Editor,

    We read with interest the article by Kauppi, Barcelos and da Silva which discussed the importance of the specific evauation of the cervical spine in the patients with rheumatoid arthritis (RA) [1]. Magnetic resonace imaging (MRI) is becoming surgical golden standard for the confirmation of compressive cervical myelopathy but is expensive and time consuming. Functional MRI is the most reliable exami...

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  • Anti-inflammatory cytokine activity in pregnant women with rheumatoid arthritis
    Roberto Gerli

    Dear Editor,

    We read with interest the analysis of pro- and anti-inflammatory cytokines in pregnant women with chronic inflammatory arthritis, such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) and ankylosing spondylitis, recently described by Oestensen et al [1].

    Besides direct measurement of cytokine serum levels, they analysed the levels of soluble CD30 (sCD30), a surface protein...

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  • Hepatitis B Virus and tumour necrosis factor alpha blocking agents
    Graham M Raftery

    Dear Editor,

    With the increasing number of patients now being treated with tumour necrosis factor alpha (TNF-alpha) blocking agents, the publication of an updated consensus statement in the Advances in Targeted Therapies VI supplement of Annals of the Rheumatic Diseases was both timely and relevant. However we notice that conflicting advice on the management of patients with Hepatitis B Virus (HBV) infection is...

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  • Infliximab therapy for refractory adult-onset Still's disease
    Petros P Sfikakis

    Dear Editor,

    We read with interest the observational, retrospective study by Fautrel and colleagues on the efficacy of anti-TNFƒÑ agents (aTNF) in refractory adult onset Still¡¦s disease (AOSD) [1].

    The authors conclude that aTNF is not as effective in AOSD as in rheumatoid arthritis (RA) or the spondyloarthrotopathies and may be helpful only in some AOSD cases. This conclusion cannot be fully supporte...

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  • A need for greater reporting of socio-economic status and race in clinical trials
    Adewale O. Adebajo

    Dear Editor,

    Lee and Kavanagh [1] report on the need for greater reporting of socio-economic status and race in clinical trials.

    This raises the wider issue of encouraging patients from ethnic minorities to participate in clinical trials in the first place.

    There are several known barriers to the involvement of ethnic minorities in clinical trials. Race often co-locates with low socio- econo...

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  • Still's disease and anti-TNF alpha therapy: the pediatric experience
    Pierre Quartier

    Dear Editor,

    Fautrel et al [1] recently reported the cases of 20 adults with Still's disease who were treated with TNF alpha blocking agents. Most patients only achieved partial remission and there were only 2 cases of sustained remission of more than one year, which contrasts with the much higher response rates observed in patients with rheumatoid arthritis.

    In this paper, the authors never refer...

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  • Antinuclear antibodies are common in an infectious environment but do not predict SLE
    Adeseye A. Adeniran

    Dear Editor,

    We read with interest the study by Cainelli et al [1] on the presence of antinuclear antibodies (ANA) in normal healthy individuals from an infectious environment. They point out that the presence of ANA may not be predictive of Systemic Lupus Erythematosus in individuals from tropical regions.

    These observations confirm previous such studies from West Africa. We would point out howev...

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  • Does Tubach’s Shortened WOMAC Function Scale Overcome the Full Length Version’s Shortcomings?
    Paul W Stratford

    Dear Editor,

    Tubach and colleagues [1] propose an 8-item shortened version of the WOMAC physical function subscale which they consider promising for clinical use and large scale surveys and clinical trials.

    The authors report that the shortened measure’s test retest reliability and responsiveness are similar to those of the complete physical function subscale; the internal consistency of the shortened...

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