eLetters

131 e-Letters

published between 2005 and 2008

  • Cervical complications of rheumatoid arthritis
    Djurdja Babic-Naglic

    Dear Editor,

    We read with interest the article by Kauppi, Barcelos and da Silva which discussed the importance of the specific evauation of the cervical spine in the patients with rheumatoid arthritis (RA) [1]. Magnetic resonace imaging (MRI) is becoming surgical golden standard for the confirmation of compressive cervical myelopathy but is expensive and time consuming. Functional MRI is the most reliable exami...

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  • Anti-inflammatory cytokine activity in pregnant women with rheumatoid arthritis
    Roberto Gerli

    Dear Editor,

    We read with interest the analysis of pro- and anti-inflammatory cytokines in pregnant women with chronic inflammatory arthritis, such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) and ankylosing spondylitis, recently described by Oestensen et al [1].

    Besides direct measurement of cytokine serum levels, they analysed the levels of soluble CD30 (sCD30), a surface protein...

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  • Hepatitis B Virus and tumour necrosis factor alpha blocking agents
    Graham M Raftery

    Dear Editor,

    With the increasing number of patients now being treated with tumour necrosis factor alpha (TNF-alpha) blocking agents, the publication of an updated consensus statement in the Advances in Targeted Therapies VI supplement of Annals of the Rheumatic Diseases was both timely and relevant. However we notice that conflicting advice on the management of patients with Hepatitis B Virus (HBV) infection is...

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  • Infliximab therapy for refractory adult-onset Still's disease
    Petros P Sfikakis

    Dear Editor,

    We read with interest the observational, retrospective study by Fautrel and colleagues on the efficacy of anti-TNFƒÑ agents (aTNF) in refractory adult onset Still¡¦s disease (AOSD) [1].

    The authors conclude that aTNF is not as effective in AOSD as in rheumatoid arthritis (RA) or the spondyloarthrotopathies and may be helpful only in some AOSD cases. This conclusion cannot be fully supporte...

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  • A need for greater reporting of socio-economic status and race in clinical trials
    Adewale O. Adebajo

    Dear Editor,

    Lee and Kavanagh [1] report on the need for greater reporting of socio-economic status and race in clinical trials.

    This raises the wider issue of encouraging patients from ethnic minorities to participate in clinical trials in the first place.

    There are several known barriers to the involvement of ethnic minorities in clinical trials. Race often co-locates with low socio- econo...

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  • Still's disease and anti-TNF alpha therapy: the pediatric experience
    Pierre Quartier

    Dear Editor,

    Fautrel et al [1] recently reported the cases of 20 adults with Still's disease who were treated with TNF alpha blocking agents. Most patients only achieved partial remission and there were only 2 cases of sustained remission of more than one year, which contrasts with the much higher response rates observed in patients with rheumatoid arthritis.

    In this paper, the authors never refer...

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  • Antinuclear antibodies are common in an infectious environment but do not predict SLE
    Adeseye A. Adeniran

    Dear Editor,

    We read with interest the study by Cainelli et al [1] on the presence of antinuclear antibodies (ANA) in normal healthy individuals from an infectious environment. They point out that the presence of ANA may not be predictive of Systemic Lupus Erythematosus in individuals from tropical regions.

    These observations confirm previous such studies from West Africa. We would point out howev...

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  • Does Tubach’s Shortened WOMAC Function Scale Overcome the Full Length Version’s Shortcomings?
    Paul W Stratford

    Dear Editor,

    Tubach and colleagues [1] propose an 8-item shortened version of the WOMAC physical function subscale which they consider promising for clinical use and large scale surveys and clinical trials.

    The authors report that the shortened measure’s test retest reliability and responsiveness are similar to those of the complete physical function subscale; the internal consistency of the shortened...

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  • NSAIDs, including coxibs, probably do more harm than good, and paracetamol is ineffective for hip OA
    Jan M. Bjordal

    Dear Editor,

    New EULAR treatment guidelines in hip osteoarthritis were recently reviewed [1]. The recommendations are allegedly based on top level scientific (grade 1a) data, and advocate the use of paracetamol (US: acetaminophen) and non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclooxygenase 2 inhibitors (coxibs), in osteoarthritis of the hip. We interpret the underlying data differently...

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  • Therapeutic potential of statins in rheumatic diseases
    Przemyslaw J. Kotyla

    Dear Editor,

    We read with a great interest article by McInnes and colleagues [1] concerning the beneficial properties of statins in patients with rheumatoid arthritis.

    HMG-CoA reductase inhibitors are widely used compounds introduced primarily as effective cholesterol lowering agents. With time, it has been recognised that effects of statins go far beyond only lipid lowering properties and nowadays they a...

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