eLetters

131 e-Letters

published between 2005 and 2008

  • Anti-TNF-alpha therapy, statins and response to influenza vaccination: a word of caution.
    Mark R Goldstein, MD

    Dear Editor,

    We read the interesting paper of Dr. Gelinck and associates on the effect of anti-tumour necrosis factor-alpha (anti-TNF-á) therapy on the antibody response to influenza vaccination [1]. Although there was a modest impairment of the antibody response to the vaccination, the proportion of patients achieving a protective titer was not significantly diminished. However, we have oncerns on generalizing these res...

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  • Re: Identification of Pneumocystis colonization in patients treated with Infliximab
    Tsutomu Takeuchi

    Dear Editor,

    We thank Dr Wissmann for the eLetter concerning Pneumocystis jiroveci pneumonia (PCP) to our article, "Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis. Ann Rheum Dis 2008;67:189-194.

    We reported that PCP developed in 22 patients among 5,000 patients with RA treated with infliximab. The organism of Pneumocysits jiroveci was not i...

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  • Cortistatin and regulatory T cell
    Kefeng Dou

    Dear Editor,

    We read with great interest the article on cortistatin (CST) treatment for collagen-induced arthritis by Gonzalez-Rey et al.(1) They reported that CST could decrease the frequency and reduce the severity of collagen-induced arthritis. In addition, they reported that CST treatment could induce the generation of regulatory T (Treg) cell in periphery. This is important, as little is presently known about th...

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  • MRI and Ultrasound of the Entheses: Perspective on Juvenile Idiopathic Arthritis
    Kay-Geert A. Hermann

    Dear Editor,

    We thank Dr. Rutkowska-Sak and colleagues for their comments on the use of ultrasound (US) for the diagnosis of enthesitis in juvenile idiopathic arthritis (JIA). The purpose of our article [1] was to bring together a global perspective on magnetic resonance imaging (MRI) for enthesitis at different sites using different methods.

    Firstly, we are interested in their comments that enthesitis...

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  • Trials in RA: choosing the right outcome measure
    Duncan Porter

    Dear Editor,

    Felson et al make a good case for choosing continuous, rather than dichotomous, variables as the primary outcome measures in randomised controlled trials in rheumatoid arthritis but outcome measure also need to be meaningful to the clinical community. In TICORA we chose two ‘co-primary’ end-points: firstly, we employed the mean change in DAS because this was the most sensitive outcome measure available at...

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  • In favor of multidisciplinary recommendations for fibromyalgia syndrome
    Andrea WM Evers

    Dear Editor,

    For complex syndromes, such as fibromyalgia, knowledge about pathophysiology and other maintaining factors is limited and there is still no optimal treatment option on how patients have to be treated. Consequently, it is important to develop guidelines based on empirical evidence or (in the case of lacking evidence) expert opinions from different disciplines. An expert team on fibromyalgia was formed and d...

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  • Stimulatory autoantibodies against PDGF receptor in scleroderma
    Armando Gabrielli

    Dear Editor,

    We read with interest the work by Balada et al. publishedin Ann Rheum Dis 2008 Feb 13; [Epub ahead of print].

    Although we noticed the authors pointed out in the title and along the text that anti-PDGFR antibodies in their study were detected by non-functional assays, we thought necessary a comment on their findings, for a better understanding of the subject, mainly for those readers who may n...

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  • The diagnostic role of ultrasonography versus magnetic resonance imaging in early diagnosis of enthe
    Lidia Rutkowska-Sak

    Dear Editor,

    This review focuses on the diagnostic role of magnetic resonance imaging (MRI) in early diagnosis of enthesitis [1]. The authors make interesting observations about the role of MRI of enthesitis –related spondyloarthritis. Enthesitis is a distinctive pathological feature of spondyloarthritis (SpA) and may involve synovial joints, cartilaginous joints, syndesmoses and extra-articular entheses. Spondyloarth...

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  • Sjögren’s syndrome with cryoglobulinemic vasculitis – successful treatment with rituximab
    Shweta S Bhagat

    Dear Editor,

    We read with interest the review on anti CD-20 monoclonal antibody treatment for cryoglobulinemic vasculitis by Cacoub et al. We share our experience with two cases of cryoglobulinemic vasculitis associated with Sjogren’s syndrome which were treated successfully with Rituximab. An 80-year-old man with Sjogren’s syndrome (SS) for 15 years, (anti-Ro/La positive, with peripheral neuropathy and immune thr...

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  • RA and diabetes mellitus: Effects of anti-TNF&[alpha] treatment on glucose metabolism
    Izhar C van Eijk

    Dear Editor, We read with great interest the recent article by Bonilla et al. about hypoglycaemia after initiation of tumour necrosis factor alpha (TNFα) blockade.[1] As many patients worldwide with rheumatic diseases are treated successfully with TNFα antagonists, there is a growing interest for possible “side” effects of these therapies, e.g. the influence of TNFα on glucose metabolism and insulin resistance. Several studi...

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