eLetters

322 e-Letters

  • Response to H Zeidler's comments on the INFAST study
    Joachim Sieper

    Dear Editor,

    In his comments about our INFAST trial (1) H Zeidler addresses the question whether a separation in patients with predominant axial and with predominant peripheral spondyloarthritis (SpA) manifestations makes sense and whether it reflects realitiy. Peripheral arthritis is one of the clinical parameters used in the classification criteria for axial (ax) SpA (2). However, it is not used here as an activ...

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  • Re: Paying attention to arbitrary causality and the preciseness of conclusion
    Changhai Ding

    Dear Editor,

    We would like to thank Dr. Lei for the comments on our paper. Please see the point-to-point response as below:

    1. As pointed out in the discussion of our paper, cross-sectional and case-control designs are not able to infer a causal relationship. The conclusion 'low grade systemic inflammation may play a greater role in symptoms rather than radiographic changes in OA' does not necessarily...

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  • Are autoantibodies to RNA-polymerase III to be incorporated in routine diagnostic laboratory algorithms for systemic autoimmune rheumatic diseases?
    Jan Damoiseaux

    Dear Editor,

    Recently a collaborative initiative of the American College of Rheumatology (ACR) and the European League against Rheumatism (EULAR) resulted in novel classification criteria for systemic sclerosis (SSc) [1]. These criteria were first selected in a derivation cohort and, next, confirmed in a validation cohort. From a laboratory perspective it is interesting that the new criteria include, besides th...

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  • Paying attention to arbitrary causality and the preciseness of conclusion
    Guang-hua Lei

    Dear Editor,

    We read with deep interest the article by Jin et al1 related to relationship between serum C reactive protein (CRP) levels measured by a high sensitivity method and osteoarthritis (OA), as well as the correlation between circulating CRP levels and OA phenotypes. We really appreciate the work which was done by the authors. However, after reading there are some worthwhile issues needs to explore....

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  • The influence of inflammation in the development of subclinical atherosclerosis in psoriatic arthritis. Comment on the article by Jamnistki et al.
    Miguel A González-Gay

    Dear Editor,

    We read with great interest the elegant systematic review on cardiovascular (CV) comorbidities in patients with psoriatic arthritis (PsA) published in the February 2013 issue of ARD by Jamnitski et al.[1] Overall, we agree that there is an increased CV risk in patients with PsA similar to that observed in patients with rheumatoid arthritis (RA).[2] Therefore, adequate CV risk stratification is also re...

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  • In response: "Paying attention to carpal tunnel contents lesions: ultrasound for evaluation of carpal tunnel syndrome"
    Christian Dejaco

    Dear Editor,

    our and several previous studies demonstrated a high diagnostic value of ultrasound for carpal tunnel syndrome (CTS) [1,2]. Among the various abnormalities within the carpal tunnel reported, the increase of the cross -sectional area (CSA) of the median nerve is the most commonly studied ultrasound abnormality [3]. In addition, ultrasound allows the identification of secondary causes of CTS such as sy...

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  • Reply to: Which B-cell subset should we target in lupus?
    Gururaj Arumugakani

    Dear Editor,

    We read with interest the editorial by Ferraccioli and Houssiau proposing the specific targeting of long lived plasma cells (PCs) in human lupus nephritis (LN) [1]. The authors present a cogent summary of experiments showing that long-lived PCs alone are sufficient to induce murine LN, and that targeting of PCs in these models is successful. However, we believe that clinical experience with the treatme...

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  • The classification criteria for Sjogren's syndrome: issues for their improvement from the study of a large Italian cohort of patients
    Luca Quartuccio

    Dear Editor,

    we read with great interest the article by Rasmussen et al. [1] which compared the performance of the new ACR [2] and the AECG [3] classification criteria for Sjogren's syndrome (SS) showing that they led to similar results when applied to a well-characterized cohort of patients with sicca symptoms. More specifically, no clear evidence for an increased value of the new ACR criteria [2] over the old AEC...

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  • When is it not ethical to withhold treatment for rheumatoid arthritis?
    Yusuf Yazici

    Dear Editor

    I read with interest the study by Takeuchi et al (1) looking at the role of monotherapy golimumab in Japanese rheumatoid arthritis (RA) patients, who had active disease despite disease modifying anti-rheumatic drug (DMARD) therapy. Inclusion criteria for the study stipulated that patients have 2/3 criteria which were: elevated inflammatory markers, erosions on radiograph or positive serology, in additio...

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  • Drug survival on TNF inhibitors: 2003-2004 data from Italian national register (GISEA Register)
    Florenzo Iannone

    Dear Editor,

    We read with interest the findings of the paper by Neovius et al recently published on Annals of the Rheumatic Diseases 1 who retrospectively studied the drug survival on TNF-alpha blockers in patients with rheumatoid arthritis (RA) in real life settings. The primary endpoint of their analysis was to assess the drug discontinuation rates in RA patients starting a first ever TNF-alpha inhibitor, and to...

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