eLetters

37 e-Letters

published between 2001 and 2004

  • "In Response to: Autoantibodies and thrombophilia in RA: TNF alpha and TNF alpha blockers-June 2004
    Alan M Mendelsohn

    Dear Editor,

    There has been growing interest in studies evaluating the effects of various disease modifying agents on endothelial dysfunction in patients with rheumatoid arthritis due to the predictive value of such properties on endothelial function on increased or decreased risk of cardiovascular events. We, therefore, read with great interest the article by Doctors Ferraciolo and Gremese in the June 2004 issue...

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  • Anakinra in the treatment of refractory adult onset Still’s disease
    Pierantonio Ostuni

    Dear Editor,

    We thank Dr Godinho and his co-authors for their report about usefulness of anakinra in the treatment of refractory adult onset Still’s disease (AOSD).

    Not all the patients with AOSD have a similar disease course: 4 different disease patterns (monocyclic systemic, monocyclic chronic articular, polycyclic systemic and polycyclic chronic articular) have been described [1]. On the other hand, c...

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  • E148Q MEFV sequence variation and familial Mediterranean fever
    Serge Amselem

    Dear Editor,

    We read with great interest the article by Topaloglu et al (Sep. 30 issue) [1] on the implication of the E148Q sequence variation in familial Mediterranean fever (FMF). In our opinion, the best interpretation of this study is not that E148Q is a disease-causing MEFV mutation, but, rather, that this sequence variation is not involved in FMF, or more precisely that the E148Q allele is not impli...

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  • Caution: under-powering a study can lead to overstated conclusions
    Anne-Maree Keenan

    Dear Editor,

    We wish to comment on the conclusions of a study recently published in Annals: A randomized controlled trial of intra-articular injection of the carpometacarpal joint of the thumb in osteoarthritis (Ann Rheum Dis 2004: 63:1260-1263).

    This study was designed as a randomized control trial, which was powered to detect a difference "between the placebo and steroid injection which was likely t...

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  • Arterial stiffness is increased in rheumatoid arthritis!
    Rainer Klocke

    Dear Editor,

    We thank Dr Chirinos for his interest in our article and appreciate his comments [1].

    We would disagree, however, with his suggestion that paired t-test is only appropriately used to analyze repeated measurements before and after an intervention in a single sample population. In our study the statistical analysis by a paired t-test was decided before data collection and based on the study d...

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  • Inappropriate use of bilateral measurements and correlations.
    Ole Rintek Madsen

    Dear Editor,

    In the paper by Schmidt et al, measurements of the left and right extremities of the same subjects seem to have been pooled to calculate standard reference values for musculoskeletal ultrasonography [1]. However, it is common knowledge that right and left measurements are tied and should not be mixed in order to get a larger “study sample”.

    In the same paper, correlations have been...

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  • Letter to Editor -- Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis
    Dennis S.C. Lam

    Dear Editor,

    We read with great interest the article by Allanore et al, and commend on their efforts in studying this important issue[1]. We would be most grateful if the authors can help to clarify a few points.

    Mean Deviation (MD) is the average of the numbers on the total deviation plot with each value weighted according to the magnitude of the normal range at that point. It signifies the over...

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  • Determining the smallest detectable change
    Jane S Angwin

    Dear Editor,

    The authors [1] are to be congratulated on demonstrating that, when readers view radiographs at 2 time-points simultaneously, they observe the relative change in JSN and/or erosions between the radiographs rather than the absolute state of the joints. Thus, they assign separate scores to the 2 radiographs to reflect this observed change, rather than scoring the 2 radiographs independently. This truth is...

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  • Comment on the Annals' choice of editorialists
    Joel A. Block

    Dear Editor,

    I was surprised to find in the current issue of Annals of the Rheumatic Diseases that the lead editorial (“Leader” in British English) was written by the co-authors of one of the manuscripts reviewed in the same editorial (1,2).

    Traditionally, readers of the peer-reviewed biomedical literature have come to expect that editorialists bring an unbiased perspective to the papers or topics bei...

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  • Arterial stiffness is increased in rheumatoid arthritis
    Rainer Klocke

    Dear Editor,

    We thank Dr Chirinos for his interest in our article and appreciate his comments [1].

    We would disagree, however, with his suggestion that paired t-test is only appropriately used to analyze repeated measurements before and after an intervention in a single sample population. In our study the statistical analysis by a paired t-test was determined before data collection and based on the stu...

    Show More

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