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Risk factors for serious infections in ANCA-associated vasculitis
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  • Published on: 10 February 2023
    Correspondence on "Risk factors for serious infections in ANCA-associated vasculitis" by Odler et al

    I am writing in regards to the article, "Risk factors for serious infections in ANCA-associated vasculitis" by Odler and colleagues, which published in the Annals of Rheumatic Diseases1. While the study provides valuable information on the risk factors for severe infections in patients with ANCA-associated vasculitis (AAV), there are certain limitations that must be taken into consideration when interpreting the results. One of the significant limitations of the study is the small sample size of only 197 patients. This limited sample size raises questions about the generalizability of the results and their statistical significance. The study results may only be applicable to the population represented in the sample and may not reflect the experiences of larger patient populations. Moreover, the small sample size may increase the likelihood of type I or type II errors and make it difficult to identify significant associations2. Another important limitation is that the study only includes participants from the RAVE trial, which is a specific population of AAV patients who meet certain inclusion criteria. Therefore, the results may not be generalizable to the broader population of AAV patients, who may have different risk factors, underlying comorbidities, and other factors that may impact the risk of severe infections3. Furthermore, the lack of a control group is another limitation of the study. The study only compared patients receiving rituximab or cyclophosphami...

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    Conflict of Interest:
    None declared.