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Anti-RuvBL1/2 autoantibodies in patients with systemic sclerosis or idiopathic inflammatory myopathy and a nuclear speckled pattern

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  • Handling editor Josef S Smolen

  • Twitter @JBVulsteke

  • EDL and XB contributed equally.

  • Contributors J-BV, EDL and XB designed the study, analysed the data and drafted the manuscript. J-BV performed the immunoprecipitation-western blot experiments. YP, CB, PV, DB, SV, KC, PDH, JLL, WAW, VS and EDL collected patient data and revised the draft manuscript. TM provided reference material and revised the draft manuscript.

  • Funding JB Vulsteke holds a Research Foundation—Flanders (FWO) SB Fellowship (1S62419N).

  • Competing interests WAW has received research grants from Roche, Boehringer-Ingelheim and Galapagos. VS has received research grants and support from Boehringer-Ingelheim and Janssen-Cilag, and research support from Accord Healthcare, UCB, and Celgene. XB was part of a scientific advisory committee for Inova Diagnostics and Thermo Fisher (outside the scope from the submitted work).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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