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Clinical characteristics of juvenile gout and treatment response to febuxostat
  1. Shaoling Zheng1,
  2. Pui Y Lee2,
  3. Yukai Huang1,
  4. Weiming Deng1,
  5. Zhixiang Huang1,
  6. Qidang Huang1,
  7. Shuyang Chen1,
  8. Tianwang Li1,3,4
  1. 1Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China
  2. 2Division of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA
  3. 3The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China
  4. 4Zhaoqing Central People‘s Hospital, Zhaoqing, Guangdong, China
  1. Correspondence to Dr Tianwang Li, Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China; litian-wang{at}163.com

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Gout is a common form of inflammatory arthritis caused by hyperuricaemia and deposition of monosodium urate crystals.1 While risk factors and comorbidities associated with gout are well established in adults,2 3 few studies have examined gout in children.4 There is no treatment guideline for juvenile gout and little is known about the efficacy of urate-lowering therapy in children. Here, we describe the clinical characteristics of 111 patients with juvenile gout evaluated in our centre between 2016 and 2020. We also present data on the efficacy of febuxostat treatment in children.

Our cohort of patients with juvenile gout (age of onset ≤18 years) consisted of 107 males and 4 females. All patients met the 2015 ACR/EULAR Criteria for gout. The mean age of symptom onset was 15.2 years and the youngest patient was 9 years old (online supplemental table 1). Compared with adult gout cases (n=533) evaluated during the same period, body mass index was comparable between the groups (p=0.097). Hypertension and kidney stones were comorbidities of gout in adults but not children. Patients with juvenile gout were more likely to provide a family history of gout in first-degree or second-degree relatives (online supplemental table 1).

Supplemental material

[annrheumdis-2021-221762supp001.pdf]

The most common site of gout attacks in children was …

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Footnotes

  • Handling editor Josef S Smolen

  • SZ and PYL contributed equally.

  • Contributors SZ, PYL and TL conceived and designed the study. SZ, WD, ZH, QH and SC acquired data. SZ, PYL and YH analysed the data. SZ, PYL and TL drafted the manuscript and all authors edited the manuscript.

  • Competing interests None declared.

  • Patient and public involvement statement This research was done without direct patient involvement beyond sample collection. Patients did not participate in designing the study, analysing the data or drafting the manuscript.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.