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Correspondence response
Response to: ‘Correspondence on ‘Preliminary predictive criteria for COVID-19 cytokine storm’’ by Tampe et al
  1. Roberto Caricchio1,
  2. Marcello Gallucci2,
  3. Chandra Dass3,
  4. Xinyan Zhang1,
  5. Stefania Gallucci4,
  6. David Fleece5,
  7. Michael Bromberg6,
  8. Gerard J Criner7
  1. 1 Medicine, Rheumatology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
  2. 2 Università degli Studi di Milano-Bicocca Facoltà di Psicologia, Milano, Lombardia, Italy
  3. 3 Radiology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
  4. 4 Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
  5. 5 Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
  6. 6 Medicine/Hematology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
  7. 7 Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA
  1. Correspondence to Professor Roberto Caricchio, Medicine, Rheumatology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; roc{at}temple.edu

https://doi.org/10.1136/annrheumdis-2020-219720

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    We thank Tampe et al 1 for their interest in our recent work, in which we describe criteria to predict worse outcome in hospitalised patients with COVID-19 and an hyperinflammatory response that we defined as cytokine storm.2 A limit of our work is that it was based on patients treated in a single hospital. It is, therefore, important that Tampe et al 1 successfully validated our criteria in an independent cohort, from a different continent and a different health system, and therefore it is a step toward criteria that can be applied to other cohorts around the world.

    We find interesting that when Tampe et al applied the criteria without ferritin and C-reactive protein (CRP), it further improved the ability of the same criteria to predict …

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    Footnotes

    • Handling editor Josef S Smolen

    • Correction notice This article has been corrected since it published Online First. The provenance and peer review statement has been included.

    • Contributors All authors have contributed to the response.

    • Funding This work was supported by the National Institutes of Health grant R56 AR072115-01 (to RC), Lupus Research Alliance (to RC).

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Commissioned; internally peer reviewed.

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