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Correspondence
Correspondence on ‘Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities’
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  1. Johan Rönnelid1,
  2. Örjan Dahlström2,
  3. Charlotte Dahle3,
  4. Christopher Sjöwall4
  1. 1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  2. 2 Behavioural Sciences and Learning, Swedish Institute for Disability Research, Linköping, Sweden
  3. 3 Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Clinical Immunology and Transfusion Medicine, Linköping University, Linköping, Sweden
  4. 4 Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden
  1. Correspondence to Associate Professor Christopher Sjöwall, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden; christopher.sjowall{at}liu.se

https://doi.org/10.1136/annrheumdis-2020-219296

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    We read with interest the recent work by Johnson and colleagues regarding their evaluation of the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for systemic lupus erythematosus (SLE) in early disease across patient groups with different ethnic background.1 Their work is important since SLE remains clinically heterogeneous, possibly due to underlying molecular diversity,2 and various sets of criteria may not necessarily perform equally well within all different populations or sexes.

    To challenge new sets of classification criteria by using retrieved clinical and laboratory data from cases with confirmed disease and cases with suspected disease, and compare their performance with older classification grounds is fair, reasonable and important. In 2015, we applied the 2012 Systemic Lupus International Collaborating Clinics (SLICC-12) criteria to 243 patients with confirmed SLE from our regional cohort and 55 control subjects with possible systemic autoimmune disease and presence of ≥1 SLE-related autoantibody. We concluded that SLICC-12 had advantages compared with older criteria with regard to diagnostic sensitivity, whereas we found the diagnostic specificity to be surprisingly low.3

    Last year, we performed a similar …

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