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  • Response to: ‘Correspondence on ‘Changing the outcome measures, changing the results? The urgent need of a specific disease activity score to adult-onset Still’s disease’’ by Muraviov and Muraviova

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Correspondence response
Response to: ‘Correspondence on ‘Changing the outcome measures, changing the results? The urgent need of a specific disease activity score to adult-onset Still’s disease’’ by Muraviov and Muraviova
  1. Piero Ruscitti1,
  2. Tanja A Stamm2,
  3. Roberto Giacomelli1
  1. 1 Department of Clinical Sciences and Applied Biotechnology, University of L'Aquila, L'Aquila, Abruzzo, Italy
  2. 2 Section for Outcomes Research, Center for Medical Statistics, Informatics and Intelligent System, Medical University of Vienna, Vienna, Austria
  1. Correspondence to Dr Roberto Giacomelli, University of L'Aquila Department of Clinical Sciences and Applied Biotechnology, L'Aquila, Abruzzo, Italy; roberto.giacomelli{at}cc.univaq.it

https://doi.org/10.1136/annrheumdis-2020-218868

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    Dear Editor,

    We read the correspondence by Muravion and Muravion1 about our previous correspondence on a recent clinical trial investigating the efficacy of canakinumab on adult-onset Still’s disease (AOSD)2 3 with interest.

    In this correspondence, Muravion and Muravion highlighted the role of disease activity score in 28 joints (DAS28) in assessing the disease activity in AOSD, also advocating American College of Rheumatology definitions of clinical response and treat-to-target recommendations.1 This is relevant in the context of rheumatoid arthritis (RA). However, it is well recognised that AOSD is a different disease from RA, considering pathogenic mechanisms, clinical features and therapeutic strategies.4 5

    Different from RA, AOSD-associated arthritis, usually an oligoarthritis, is present in two-thirds of these patients, migrating between joints at the very beginning and becoming stable within the course of the disease.6 Although any joint might be affected, wrists, knees and ankles are frequently involved in AOSD arthritis. However, proximal interphalangeal and metacarpophalangeal joints of the hands and small joints of the feet, including …

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    Footnotes

    • Handling editor Josef S Smolen

    • Contributors All the authors met all criteria for authorship in the ICMJE Recommendations, since all authors made substantial contributions to the conception or design of the work, the acquisition and interpretation of data. All authors contributed to the critical review and revision of the manuscript and approved the final version. All the authors agreed to be accountable for all aspects of the work.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

    • Provenance and peer review Commissioned; internally peer reviewed.

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