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  • Correspondence on ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’

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Correspondence
Correspondence on ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’
  1. Maria Vincenza Mastrolia1,
  2. Rino Agostiniani2,
  3. Chiara Azzari3,
  4. Roberto Bernardini4,
  5. Ugo Bottone5,
  6. Giovanni Battista Calabri6,
  7. Flavio Civitelli7,
  8. Rita Consolini8,
  9. Roberto Danieli9,
  10. Rosalia Di Silvio10,
  11. Susanna Falorni11,
  12. Luigi Gagliardi12,
  13. Salvatore Grosso13,
  14. Marco Martini14,
  15. Graziano Memmini15,
  16. Diego Peroni16,
  17. Marco Pezzati17,
  18. Giovanni Suriano18,
  19. Luca Tafi19,
  20. Angelina Vaccaro20,
  21. Pier Luigi Vasarri21,
  22. Gabriele Simonini22
  23. On behalf of the Paediatric Tuscany Network
  1. 1 Rheumatology Unit, Meyer Children’s University Hospital, Firenze, Italy
  2. 2 Pediatric Unit, San Jacopo Hospital, Pistoia, Italy
  3. 3 Department of Health Science, Pediatric Immunology Unit, Meyer Children’s University Hospital, Firenze, Italy
  4. 4 Pediatric Unit, San Giuseppe Hospital, Empoli, Italy
  5. 5 Division of Neonatology and Pediatrics, Lotti Hospital, Pontedera, AUSL Toscana Nord Ovest, Pisa, Italy
  6. 6 Cardiology Unit, Meyer Children’s University Hospital, Firenze, Italy
  7. 7 Division of Neonatology and Pediatrics, Montepulciano Hospital, Montepulciano, AUSL Toscana Sud Est, Siena, Italy
  8. 8 Department of Clinical and Experimental Medicine, Section of Clinical and Laboratory Immunology, University of Pisa, Pisa, Italy
  9. 9 Division of Neonatology and Pediatrics, Spedali Riuniti di Livorno, AUSL Toscana Nord Ovest, Livorno, Italy
  10. 10 Pediatric Unit, Mugello Hospital, Borgo San Lorenzo, Firenze, Italy
  11. 11 Pediatric Unit, Misericordia Hospital, Grosseto, Italy
  12. 12 Division of Neonatology and Pediatrics, Versilia Hospital, Viareggio, AUSL Toscana Nord Ovest, Pisa, Italy
  13. 13 Department of Molecular Medicine and Development, University of Siena, Clinical Pediatrics, Siena, Italy
  14. 14 Pediatric Unit, San Donato Hospital, Arezzo, Italy
  15. 15 Division of Neonatology and Pediatrics, Apuane Hospital, AUSL Toscana Nord Ovest, Massa Carrara, Italy
  16. 16 Section of Pediatrics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
  17. 17 Pediatric Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, AUSL Toscana Centro, Firenze, Italy
  18. 18 Division of Neonatology and Pediatrics, Cecina Hospital, Cecina, AUSL Toscana Nord Ovest, Pisa, Italy
  19. 19 Paediatric and Neonatal Unit, Valdarno Hospital, Montevarchi, Arezzo, Italy
  20. 20 Division of Neonatology and Pediatrics, San Luca Hospital, AUSL Toscana Nord Ovest, Lucca, Italy
  21. 21 Paediatric and Neonatologic Unit, Santo Stefano Hospital, Prato, Italy
  22. 22 Rheumatology Unit, Department Neurofarba, Meyer Children’s University Hospital, Firenze, Italy
  1. Correspondence to Dr Gabriele Simonini, Rheumatology Unit, Meyer Children's University Hospital, Department NEUROFARBA, Firenze 50139, Italy; gabriele.simonini{at}unifi.it

https://doi.org/10.1136/annrheumdis-2020-218797

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    We read with interest the clinical study entitled ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’ by Pouletty et al.1 In this series, the authors suggest that paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PMIS-TS) may represent a new inflammatory syndrome, different from classical Kawasaki disease (KD) as it occurs at an older age, and with a higher frequency of severe myocarditis.1

    Likewise to this study, our Pediatric Tuscany Network (PTN)—16 paediatric units serving a region of 593 606 people aged less than 18 years—worked out the COVASAKI survey to detect the incidence of PMIS-TS cases and the eventual rise of KD in Tuscany during COVID-19 pandemic. Between 1 February 2000 and 30 June 2020, we tracked children with PMIS-TS and KD, aiming to compare the number of KD cases in the same 5 months of the previous 5 years and overall with the total number in the last 5 years.

    No PMIS-TS cases were reported in our region. Ten KD children were diagnosed in 5 units (incidence two per month). Demographics, clinical and imaging findings, treatment and outcome of patients are reported in table 1. No specific intensive support was required. No coronary involvement was reported. Nasopharyngeal swabs (performed in 7/10) and serological …

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    Footnotes

    • RA, CA, RB, UB, GBC, FC, RC, RD, RDS, SF, LG, SG, MM, GM, DP, MP, GS, LT, AV, PLV and GS contributed equally.

    • Contributors GS and CA conceptualised and designed the study. GS and MVM drafted the initial manuscript. GS coordinated and supervised data collection, carried out the initial analyses and critically reviewed the manuscript for important intellectual content. RA, RB, UB, GBC, FC, RC, RD, RDS, SF, LG, SG, MM, GM, DP, MP, GS, LT, AV, and PLV actively contributed to the study development at their sites, data collection and development of the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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