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We read with interest the correspondence from Mizugishi et al.1 The pathophysiology of Kawasaki disease (KD) and more recently Kawasaki-like paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) or Kawa-COVID-19 remains largely unknown, even if the infectious trigger by SARS-CoV-2 in the prior weeks seems to be a key feature.2 Furthermore, it is still uncertain whether Kawasaki-like PIMS-TS can be considered as the same entity as KD or if it should be individualised as a novel distinct condition, as it may have been suggested with several significant clinical and biological differences between classical KD and Kawa-COVID-19.3
Mizugishi et al 1 speculate that KD and Kawa-COVID-19 share a common pathophysiology through excessive neutrophil extracellular trap (NET) formation. Similar to Yoshida et al,4 Mizugishi et al 1 showed increased NET formation in KD patients sera. Through a KD mouse model, the authors describe that severe vasculitis (in the aorta and coronary arteries) was associated with infiltrative neutrophils. Those neutrophils were primed to produce NETs through the PAD4 pathway and seemed to produce a specific type of NET formation (enriched in citrullinated histones). Excessive NET formation was also described in sera of adult COVID-19 patients with endothelial injuries. Kawa-COVID-19 could represent a severe form of KD triggered by an exaggerated NET formation induced by SARS-CoV-2.
NETs are an important first-line defence mechanism against bacterial, viral, fungal and parasitic infections, but they have been also suspected to play a role in autoimmune diseases such as systemic lupus erythematosus (SLE) or antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) for example.5 Van Dam et al 5 showed that NET formation is involved in the pathophysiology of two clinically and pathologically distinct forms …