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Incidence of venous and arterial thromboembolic events reported in the tofacitinib rheumatoid arthritis, psoriasis and psoriatic arthritis development programmes and from real-world data
  1. Philip Mease1,
  2. Christina Charles-Schoeman2,
  3. Stanley Cohen3,
  4. Lara Fallon4,
  5. John Woolcott5,
  6. Huifeng Yun6,
  7. Joel Kremer7,
  8. Jeffrey Greenberg8,
  9. Wendi Malley8,
  10. Alina Onofrei8,
  11. Keith S Kanik9,
  12. Daniela Graham9,
  13. Cunshan Wang10,
  14. Carol Connell11,
  15. Hernan Valdez12,
  16. Manfred Hauben13,14,
  17. Eric Hung13,
  18. Ann Madsen15,
  19. Thomas V Jones16,
  20. Jeffrey R Curtis17
  1. 1Rheumatology Clinical Research Division, Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, Washington, USA
  2. 2Division of Rheumatology, University of California, Los Angeles, California, USA
  3. 3Metroplex Research Center, Dallas, Texas, USA
  4. 4Inflammation and Immunology – Global Medical Affairs, Pfizer Inc, Kirkland, Quebec, Canada
  5. 5Inflammation and Immunology, Pfizer Inc, Collegeville, Pennsylvania, USA
  6. 6Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
  7. 7Albany Medical College and The Center for Rheumatology, Albany, New York, USA
  8. 8Corrona LLC, Waltham, Massachusetts, USA
  9. 9Inflammation and Immunology TA, Pfizer Inc, Groton, Connecticut, USA
  10. 10Statistics, Global Product Development, Pfizer Inc, Groton, Connecticut, USA
  11. 11Clinical Development & Operations, Pfizer Inc, Groton, Connecticut, USA
  12. 12Global Product Development, Inflammation and Immunology, Pfizer Inc, New York, New York, USA
  13. 13Worldwide Safety, Pfizer Inc, New York, New York, USA
  14. 14Department of Medicine, NYU Langone Health, New York, New York, USA
  15. 15Global Medical Epidemiology, Pfizer Inc, New York, New York, USA
  16. 16Worldwide Medical and Safety, Pfizer Inc, Collegeville, Pennsylvania, USA
  17. 17Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
  1. Correspondence to Philip Mease, Seattle Rheumatology Associates, 601 Broadway, Suite 600, Seattle, WA 98102, USA; pmease{at}philipmease.com

Abstract

Objectives Tofacitinib is a Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ulcerative colitis, and has been investigated in psoriasis (PsO). Routine pharmacovigilance of an ongoing, open-label, blinded-endpoint, tofacitinib RA trial (Study A3921133; NCT02092467) in patients aged ≥50 years and with ≥1 cardiovascular risk factor identified a higher frequency of pulmonary embolism (PE) and all-cause mortality for patients receiving tofacitinib 10 mg twice daily versus those receiving tumour necrosis factor inhibitors and resulted in identification of a safety signal for tofacitinib. Here, we report the incidence of deep vein thrombosis (DVT), PE, venous thromboembolism (VTE; DVT or PE) and arterial thromboembolism (ATE) from the tofacitinib RA (excluding Study A3921133), PsA and PsO development programmes and observational studies. Data from an ad hoc safety analysis of Study A3921133 are reported separately within.

Methods This post-hoc analysis used data from separate tofacitinib RA, PsO and PsA programmes. Incidence rates (IRs; patients with events per 100 patient-years’ exposure) were calculated for DVT, PE, VTE and ATE, including for populations stratified by defined baseline cardiovascular or VTE risk factors. Observational data from the US Corrona registries (including cardiovascular risk factor stratification), IBM MarketScan research database and the US FDA Adverse Event Reporting System (FAERS) database were analysed.

Results 12 410 tofacitinib-treated patients from the development programmes (RA: n=7964; PsO: n=3663; PsA: n=783) were included. IRs (95% CI) of thromboembolic events among the all tofacitinib cohorts’ average tofacitinib 5 mg and 10 mg twice daily treated patients for RA, respectively, were: DVT (0.17 (0.09–0.27) and 0.15 (0.09–0.22)); PE (0.12 (0.06–0.22) and 0.13 (0.08–0.21)); ATE (0.32 (0.22–0.46) and 0.38 (0.28–0.49)). Among PsO patients, IRs were: DVT (0.06 (0.00–0.36) and 0.06 (0.02–0.15)); PE (0.13 (0.02–0.47) and 0.09 (0.04–0.19)); ATE (0.52 (0.22–1.02) and 0.22 (0.13–0.35)). Among PsA patients, IRs were: DVT (0.00 (0.00–0.28) and 0.13 (0.00–0.70)); PE (0.08 (0.00–0.43) and 0.00 (0.00–0.46)); ATE (0.31 (0.08–0.79) and 0.38 (0.08–1.11)). IRs were similar between tofacitinib doses and generally higher in patients with baseline cardiovascular or VTE risk factors. IRs from the overall Corrona populations and in Corrona RA patients (including tofacitinib-naïve/biologic disease-modifying antirheumatic drug-treated and tofacitinib-treated) with baseline cardiovascular risk factors were similar to IRs observed among the corresponding patients in the tofacitinib development programme. No signals of disproportionate reporting of DVT, PE or ATE with tofacitinib were identified in the FAERS database.

Conclusions DVT, PE and ATE IRs in the tofacitinib RA, PsO and PsA programmes were similar across tofacitinib doses, and generally consistent with observational data and published IRs of other treatments. As expected, IRs of thromboembolic events were elevated in patients with versus without baseline cardiovascular or VTE risk factors, and were broadly consistent with those observed in the Study A3921133 ad hoc safety analysis data, although the IR (95% CI) for PE was greater in patients treated with tofacitinib 10 mg twice daily in Study A3921133 (0.54 (0.32–0.87)), versus patients with baseline cardiovascular risk factors treated with tofacitinib 10 mg twice daily in the RA programme (0.24 (0.13–0.41)).

  • rheumatoid arthritis
  • psoriatic arthritis
  • DMARDs (synthetic)
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Key messages

What is already known about this subject?

  • The risk of venous thromboembolism (VTE) (including deep vein thrombosis (DVT) and pulmonary embolism (PE)) and arterial thromboembolism (ATE) is elevated in patients with immune-mediated inflammatory diseases such as rheumatoid arthritis (RA), psoriasis (PsO) and psoriatic arthritis (PsA). Labelling for the Janus kinase (JAK) inhibitors tofacitinib, baricitinib and upadacitinib now includes thrombosis as a warning and/or as an adverse drug reaction, with specific variations according to region, country and JAK inhibitor.

  • In February 2019, a safety analysis of Study A3921133 (NCT02092467)—an ongoing, postauthorisation safety surveillance study in RA patients aged ≥50 years and with ≥1 cardiovascular risk factor—completed by the Data Safety Monitoring Board reported an increased incidence of PE events and all-cause mortality in patients treated with tofacitinib 10 mg twice daily versus tumour necrosis factor inhibitors.

  • DVT and PE events have been observed in the tofacitinib ulcerative colitis programme (phase 2, 3 and open-label extension studies); incidence rates (IRs; patients with events per 100 patient-years’ exposure) were 0.04 (95% CI 0–0.23) and 0.16 (0.04–0.41), respectively.

Key messages

What does this study add?

  • Analysis of data from the tofacitinib RA (excluding Study A3921133), PsO and PsA programmes shows DVT, PE and ATE IRs to be higher in patients with defined baseline cardiovascular or VTE risk factors versus those without, and consistent with IRs in cardiovascular risk factor-enriched patients from observational data. IRs in patients with baseline cardiovascular risk factors in the RA programme were broadly comparable to those in the ad hoc safety analysis of Study A3921133, although the IR (95% CI) for PE was higher in patients treated with tofacitinib 10 mg twice daily in Study A3921133 (0.54 (0.32–0.87)), versus patients with baseline cardiovascular risk factors treated with tofacitinib 10 mg twice daily in the RA programme (0.24 (0.13–0.41)).

How might this impact on clinical practice or future developments?

  • VTE has been determined to be an important identified risk of tofacitinib treatment, and local labelling has been updated regarding risk factors for thromboembolism to reflect the ad hoc safety analysis of Study A3921133 and knowledge of the JAK inhibitor safety profile. Further research is needed to better understand the relationship between thromboembolic events and JAK inhibitors, including tofacitinib.

Introduction

Tofacitinib is a Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ulcerative colitis (UC), and has been investigated in psoriasis (PsO; approved for use in moderate to severe plaque PsO in Russia only). Labelling for the JAK inhibitors tofacitinib,1 2 baricitinib3 4 and upadacitinib5 6 now includes thrombosis as a warning and/or as an adverse drug reaction, with specific labelling varying by region or country, and by individual JAK inhibitor.

Inflammation is a risk factor for venous thromboembolism (VTE)—including deep vein thrombosis (DVT) and pulmonary embolism (PE)—and arterial thromboembolism (ATE).7–9 Several attributes (including inflammatory diseases), family history, older age, Black race, smoking, hypertension, diabetes, cancer, hormone therapy, major surgical procedures, obesity and immobilisation are risk factors for VTE.7 9–17 Increased incidence of VTE and ATE relative to the general population has been reported in patients with immune-mediated inflammatory diseases, including RA,18–30 PsO22 24 25 31–37 and PsA.22 38 39

An ongoing, randomised, open-label, blinded-endpoint (major adverse cardiovascular events (MACE) and malignancies excluding non-melanoma skin cancers), postauthorisation study in RA patients—Study A3921133 (ClinicalTrials.gov NCT02092467)—is evaluating the safety of tofacitinib 5 mg twice daily and tofacitinib 10 mg twice daily versus tumour necrosis factor inhibitors (TNFi) among patients with cardiovascular risk factors.40 In February 2019, during routine analysis of all safety events, the external, independent tofacitinib Rheumatology Data Safety Monitoring Board reported that, in the ongoing Study A3921133, among other findings, the frequency of PE and all-cause mortality in patients receiving tofacitinib 10 mg twice daily was higher than in patients treated with a TNFi (full data set is not yet available).1 41

In order to better understand VTE and ATE in RA, PsO and PsA patients receiving tofacitinib, we present data from the overall RA, PsO and PsA development programmes; this analysis also includes patients in the development programmes randomised to adalimumab and methotrexate. The incidence rates (IRs; 95% CI) of DVT and PE in the tofacitinib UC programme have been previously reported (0.04 (0–0.23) and 0.16 (0.04–0.41), respectively).42 We also report thrombotic events stratified by the presence or absence of elevated baseline cardiovascular risk (aligned as closely as possible with the inclusion criteria of Study A3921133, listed in the online supplementary text) and elevated VTE risk, measured at baseline (cardiovascular and VTE risk factors are listed in the methods), as well as the results of an ad hoc safety analysis of Study A3921133. Additional context for the observed IRs is provided through the reporting of observational data in RA, PsO and PsA patients from the US Corrona registries, IBM MarketScan research database and the US FDA Adverse Event Reporting System (FAERS) database.

Methods

Clinical data

This was a posthoc analysis of safety data from phase 1 to 3, 3b/4 and long-term extension (LTE) clinical studies of tofacitinib in RA patients, from phase 2 to 3 and LTE studies of tofacitinib in PsO patients, and from phase 3 and LTE studies of tofacitinib in PsA patients. As Study A3921133 remains ongoing, its data were not included in these pooled analyses for any RA cohort; however, data from an ad hoc safety analysis are reported separately here (data have not yet been source-verified or subjected to standard quality-check procedures that would occur at the time of database lock, and may therefore be subject to change).1

Full details of study designs and inclusion/exclusion criteria for each completed study have previously been published (online supplementary table S1). The ongoing Study A3921133 (NCT02092467; data cut-off February 2019; database not locked; data have not yet been source-verified or subjected to standard quality-check procedures that would occur at the time of database lock, and may therefore be subject to change) has enrolled patients aged ≥50 years and with ≥1 cardiovascular risk factor, receiving a stable dose of methotrexate (cardiovascular risk factors and inclusion/exclusion criteria are reported in the online supplementary material). Studies were conducted in accordance with the Declaration of Helsinki, the International Conference on Harmonization Guidelines for Good Clinical Practice, and local regulations.

RA patients received tofacitinib immediate-release twice daily or in a modified-release formulation (once daily) either as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs); all PsA patients received tofacitinib immediate-release twice daily in combination with one csDMARD; all PsO patients received tofacitinib immediate-release twice daily as monotherapy.

Three posthoc analysis cohorts were defined for each of the three separate programmes (RA, PsO and PsA): placebo-controlled cohort, dose-comparison and active-control cohort and all tofacitinib cohort; further details on each cohort are given in the online supplementary material. The placebo-controlled cohort included patients randomised to tofacitinib 5 or 10 mg twice daily or placebo up to month 3 (before any placebo-treated patients advanced to tofacitinib). The dose-comparison and active-control cohort included data from patients treated for ≤24 months for RA and ≤12 months for PsO and PsA, randomised to tofacitinib 5 or 10 mg twice daily (including those who advanced from placebo in the PsO and PsA programmes), adalimumab 40 mg subcutaneous once every 2 weeks (active control in one phase 2 RA study, one phase 3 RA study and one phase 3 PsA study; active comparator in one phase 3/4b RA study), or methotrexate ≤20 mg once weekly (comparator in one phase 2 and one phase 3 RA study). The all tofacitinib cohort encompassed all patients in each disease programme who received ≥1 dose of tofacitinib (primarily 5 or 10 mg twice daily or 11 mg once daily) in RA (≤114 months’ tofacitinib exposure; final data as of 18 January 2019), PsO (≤66 months’ tofacitinib exposure; final data as of 18 August 2016) and PsA (≤62 months’ tofacitinib exposure; final data as of 31 July 2019) studies.

For the RA, PsO and PsA all tofacitinib cohort, dose group was categorised using two methods, as patients could change doses between the index and LTE studies, and within the LTE studies. For the average-dosing algorithm, patients were assigned to average tofacitinib 5 or 10 mg twice daily if the average total daily dose over the course of observation was <15 or ≥15 mg, respectively. For the constant-dosing algorithm, only patients exposed to a constant tofacitinib dose of 5 or 10 mg twice daily without prior exposure to a different tofacitinib dose or adalimumab were included in the algorithm; exposure and events captured after a dose switch were excluded from the constant-dose analysis.

Data were not pooled across RA, PsO and PsA. In the described posthoc analysis of the three cohorts, all available patient-level data was used, with no exclusion criteria applied specifically related to VTE or ATE.

Additional analyses within the pooled RA, PsO and PsA clinical trial data sets were conducted. Patients were stratified by the presence or absence of defined baseline cardiovascular or VTE risk factors. Patients were identified as having cardiovascular risk factors at baseline if they were aged ≥50 years and met ≥1 of the following criteria: current smoker, high-density lipoprotein (HDL) <40 mg/dL, history of hypertension diagnosis, history of diabetes diagnosis, history of myocardial infarction or history of coronary heart disease diagnosis; this definition of cardiovascular risk factors is similar to that used in the inclusion criteria of Study A39211331 40 and a recently completed trial of a TNFi (etanercept) versus an interleukin-6 inhibitor (tocilizumab) in RA patients with cardiovascular risk factors (ENTRACTE).43 For the purposes of this analysis, patients were identified as having VTE risk factors if they met any of the following criteria at baseline: aged ≥60 years, current smoker, previous heart failure, previous VTE (DVT or PE), body mass index (BMI) ≥30 kg/m2, Day 1 use of oral contraceptives or hormone replacement therapy, Day 1 use of antidepressants or Day 1 use of aspirin. Please note that this definition of VTE risk factors is specific to this analysis and reflects available data from the clinical trials; for this reason, it may differ to definitions used elsewhere.

DVT, PE and ATE events were identified using the Medical Dictionary for Regulatory Activities (MedDRA) selected (clinically relevant) Preferred Terms (PTs) from the Standardised MedDRA Queries (SMQs) Embolic and thrombotic events, venous and Embolic and thrombotic events, arterial (including PT for cases of myocardial infarction and ischaemic stroke). Given the potential that some PTs, consistent with DVT and ATE, are not included in the above SMQs, the database was also examined for clinically relevant terms for the SMQ Embolic and thrombotic events, vessel type unspecified and mixed arterial and venous. Details are given in the online supplementary material. PTs were based on spontaneous reporting of adverse events by investigators and were not corroborated or confirmed by any protocol-mandated assessment or activity.

IRs were calculated as the number of patients with an event per 100 patient-years (PY) of exposure, defined as time to first event occurring during the risk period (minimum of a patient’s last treatment dose date plus 28 days, date of death or up to the last observation date). Poisson 95% CIs for the IRs were calculated.

Separate IRs were calculated for DVT, PE and ATE events (including both outpatient and inpatient events), and for VTE (a composite of the first DVT or PE event). Patients who experienced more than one event were censored at the time of first event. For patients who experienced multiple events at the same time, each event was included in the DVT, PE and ATE IR estimates, respectively. For VTE event (DVT or PE) IR estimates, the patient was only included once, even if there was simultaneous reporting of DVT and PE in the same patient.

Kaplan-Meier analysis was performed for time to DVT, PE or ATE; total follow-up time was calculated up to the day of the first event (subject to the above risk period).

Observational/postmarketing data

For all observational data from the relevant US Corrona registries and MarketScan database, the IRs were calculated as patients with events per 100 PY of exposure (Corrona) or as events per 100 PY of exposure (MarketScan). Rates were standardised by age and sex distribution for each disease in the tofacitinib programme, unless otherwise stated (details given in the online supplementary material).

Data were obtained from the US Corrona registries44 for RA, PsO or PsA patients who received non-biologic or biologic treatments (online supplementary table S2) from 6 November 2012 for RA, 1 April 2015 for PsO or 1 March 2013 for PsA, up to 31 December 2017. Exposure time was defined as the time in years from the index date (first date of prescription or administration of approved treatment after diagnosis) to the first VTE event (DVT or PE), last follow-up visit, or switch to tofacitinib, whichever came first.

An additional subanalysis within the RA Corrona-based postauthorisation safety study of tofacitinib45 investigated the incidence of DVT and PE events in cohorts of patients with moderate to severe RA (Clinical Disease Activity Index (CDAI)>10 at initiation) initiating a biologic disease-modifying antirheumatic drug (bDMARD) or tofacitinib, who were aged ≥50 years and had ≥1 cardiovascular risk factor (details in the online supplementary material). Non-standardised/unadjusted (crude) IRs were calculated. The time to first DVT or PE event was also calculated.

Data were also obtained and analysed from the IBM MarketScan research database (hereafter MarketScan database)46 for RA, PsO or PsA patients treated between 1 January 2010 and 31 December 2017 (online supplementary material). Exposure time was defined as the time in years from the index date to the first DVT or PE event, identified using ICD9/10 diagnosis codes and patient medication use.

Using the FAERS database, disproportionality analyses were performed on spontaneous reports to assess if there was a signal of disproportionate reporting (SDR) through analysis of observed-to-expected (O/E) reporting frequencies. Analyses were completed for the identified events of Embolic and thrombotic events, venous, Embolic and thrombotic events, arterial and Embolic and thrombotic events, vessel type unspecified and mixed arterial and venous SMQs reported in association with tofacitinib. For the shrinkage-adjusted O/E, an SDR was defined as a lower 5% bound of the 90% interval of the shrinkage-adjusted O/E ratio (EB05) >2.47 For the unadjusted metric, an SDR was defined as the lower 5% bound of the 90% interval of the reporting odds ratio (ROR05) >2 and a minimum case count >2.

Patient and public involvement

Patients and the public were not involved in the design, analysis or results interpretation of this study. Patient-level data from the relevant data sets were used to complete the analysis.

Results

Tofacitinib clinical trials

Patients

Overall, 12 410 tofacitinib-exposed patients from completed studies in the development programmes were included in this analysis: 7964 with RA, 3663 with PsO and 783 with PsA. Table 1 summarises demographics and baseline characteristics for all patients who received ≥1 dose of tofacitinib. Online supplementary tables S3–5 summarise the demographics and baseline characteristics data, stratified by the presence or absence of baseline cardiovascular or VTE risk factors.

Table 1

Patient demographics and baseline characteristics for all tofacitinib-treated patients (all tofacitinib cohort) in completed studies in the RA, PsO and PsA development programmes, stratified by average tofacitinib dose*

Incidence of VTE and ATE: placebo-controlled cohort

During the first 90 days of tofacitinib treatment (up to month 3 in the placebo-controlled cohorts), the IRs of DVT, PE, VTE (DVT or PE) and ATE events were similar between tofacitinib doses and placebo across each of the RA (figure 1), PsO (figure 2) and PsA (figure 3) development programmes.

Figure 1

Drug exposure and incidence rates (95% CI) among RA patients in completed studies in the tofacitinib development programme for (A) the placebo-controlled cohort, (B) the dose-comparison and active-control cohort, and the all tofacitinib cohort for (C) DVT,(D) PE, (E) VTE (DVT or PE) and (F) ATE, including patients stratified by baseline cardiovasculara or VTEb risk factors; final data as of 18 January 2019. aBaseline cardiovascular risk factors were defined as any patient aged ≥50 years and meeting ≥1 of the following criteria at baseline: current smoker, HDL <40 mg/dL, history of hypertension diagnosis, history of diabetes diagnosis, history of myocardial infarction or history of coronary heart disease diagnosis. bBaseline VTE risk factors were defined as any patient meeting any of the following criteria at baseline: aged ≥60 years, current smoker, previous heart failure, previous VTE (DVT or PE), BMI ≥30 kg/m2, Day 1 use of oral contraceptives or hormone replacement therapy, Day 1 use of antidepressants or Day 1 use of aspirin. cOne or dtwo patients were not counted in the numerator of the IR calculations because the events occurred outside the defined risk period. eOne patient experienced both DVT and PE. ATE, arterial thromboembolism; BID, twice daily; BMI, body mass index; DVT, deep vein thrombosis; HDL, high-density lipoprotein; IR, incidence rate (number of patients with an event per 100 PY of exposure); MTX, methotrexate; N, total number of patients; n, number of patients with an event; PE, pulmonary embolism; PY, patient-years; QW, once a week; Q2W, once every 2 weeks; RA, rheumatoid arthritis; SC, subcutaneous; VTE, venous thromboembolism.

Figure 2

Drug exposure and incidence rates (95% CI) among PsO patients in completed studies in the tofacitinib development programme for (A) the placebo-controlled cohort, (B) the dose-comparison and active-control cohort,a and the all tofacitinib cohort for (C) DVT, (D) PE, (E) VTE (DVT or PE) and (F) ATE, including patients stratified by baseline cardiovascularb or VTEc risk factors; final data as of 18 August 2016. aThe dose-comparison and active-control cohort includes patients receiving tofacitinib after switching from placebo. bBaseline cardiovascular risk factors were defined as any patient aged ≥50 years and meeting ≥1 of the following criteria at baseline: current smoker, HDL <40 mg/dL, history of hypertension diagnosis, history of diabetes diagnosis, history of myocardial infarction or history of coronary heart disease diagnosis. cBaseline VTE risk factors were defined as any patient meeting any of the following criteria at baseline: aged ≥60 years, current smoker, previous heart failure, previous VTE (DVT or PE), BMI ≥30 kg/m2, Day 1 use of oral contraceptives or hormone replacement therapy, Day 1 use of antidepressants or Day 1 use of aspirin. dOne, ethree or ffour patients were not counted in the numerators of the IR calculations because the events occurred outside the defined risk period. ATE, arterial thromboembolism; BID, twice daily; BMI, body mass index; DVT, deep vein thrombosis; HDL, high-density lipoprotein; IR, incidence rate (number of patients with an event per 100 PY of exposure); N, total number of patients; n, number of patients with an event; PE, pulmonary embolism; PsO, psoriasis; PY, patient-years; VTE, venous thromboembolism.

Figure 3

Drug exposure and incidence rates (95% CI) among PsA patients in completed studies in the tofacitinib development programme for (A) the placebo-controlled cohort, (B) the dose-comparison and active-control cohort, and the all tofacitinib cohort for (C) DVT, (D) PE, (E) VTE (DVT or PE) and (F) ATE, including patients stratified by baseline cardiovasculara or VTEb risk factors; final data as of 31 July 2019. aBaseline cardiovascular risk factors were defined as any patient aged ≥50 years and meeting ≥1 of the following criteria at baseline: current smoker, HDL <40 mg/dL, history of hypertension diagnosis, history of diabetes diagnosis, history of myocardial infarction or history of coronary heart disease diagnosis. bBaseline VTE risk factors were defined as any patient meeting any of the following criteria at baseline: aged ≥60 years, current smoker, previous heart failure, previous VTE (DVT or PE), BMI ≥30 kg/m2, Day 1 use of oral contraceptives or hormone replacement therapy, Day 1 use of antidepressants or Day 1 use of aspirin. cOne patient was not counted in the numerators of the IR calculations because the event occurred outside the defined risk period. ATE, arterial thromboembolism; BID, twice daily; BMI, body mass index; DVT, deep vein thrombosis; HDL, high-density lipoprotein; IR, incidence rate (number of patients with an event per 100 PY of exposure); N, total number of patients; n, number of patients with an event; PE, pulmonary embolism; PsA, psoriatic arthritis; PY, patient-years; Q2W, once every 2 weeks; SC, subcutaneous; VTE, venous thromboembolism.

One patient with RA receiving placebo experienced both a DVT and a PE event; this patient was aged >50 years and had multiple risk factors, including current smoker, medical history of thrombosis and Day 1 use of hormone replacement therapy and antidepressants.

Incidence of VTE and ATE: dose-comparison and active-control cohort

In RA up to month 24, and in PsO and PsA up to month 12, IRs of DVT, PE, VTE (DVT or PE) and ATE events were similar between tofacitinib (both doses), adalimumab and methotrexate (figures 1–3).

Incidence of VTE and ATE: all tofacitinib cohort—all patients

Among RA (figure 1), PsO (figure 2) and PsA (figure 3) patients, the IRs of all events were similar for average tofacitinib 5 and 10 mg twice daily. Among RA patients, IRs for constant tofacitinib 10 mg twice daily were similar to those for constant tofacitinib 5 mg twice daily.

Analysis of Kaplan-Meier curves, showing proportions of RA patients in the tofacitinib development programme without a thromboembolic event, did not reveal any separation between dose groups, and most events occurred during the LTE. More events occurring during the LTE can be attributed to the longer observation time in the LTE versus the index studies. Further, the curves indicated a consistent rate of event occurrence over time (online supplementary figure S1). Thromboembolic events among PsO and PsA patients were too few to be represented in Kaplan-Meier curves.

Analysis of the SMQ Embolic and thrombotic events, vessel type unspecified and mixed arterial and venous—to identify additional PTs consistent with VTE/ATE—revealed one patient each with cerebral thrombosis (RA programme; average 5 mg twice daily), intracardiac thrombus (RA programme; average 10 mg twice daily) and thrombotic stroke (PsO programme; average 10 mg twice daily). These events were not included in the IR calculations.

Incidence of VTE and ATE: all tofacitinib cohort—stratified by baseline cardiovascular or VTE risk factors

The IRs of DVT, PE, VTE (DVT or PE) and ATE were generally higher in patients with a baseline cardiovascular or VTE risk factor versus patients without (figures 1–3). IRs were lower in RA patients without risk factors (61% with no cardiovascular risk factors; 34% with no VTE risk factors) versus those with risk factors. Among PsA patients, all DVT and PE events were experienced by patients who had baseline cardiovascular or VTE risk factors. However, across all diseases, comparison of thromboembolic event IRs in patients with baseline cardiovascular or VTE risk was limited by the low number of events and did not illustrate meaningful differences across groups.

IRs were similar between average tofacitinib 5 and 10 mg twice daily among patients with cardiovascular or VTE risk factors (figures 1–3). For RA patients without cardiovascular or VTE risk factors, IRs of DVT, PE and VTE (but not ATE) were modestly numerically higher for average tofacitinib 10 mg twice daily relative to average tofacitinib 5 mg twice daily, but the number of events across all diseases in patients without risk factors was too low to draw firm conclusions.

Incidence of DVT and PE: Study A3921133 (ad hoc safety analysis)

The ongoing Study A3921133 includes 4362 randomised patients, and is accruing safety and efficacy data as specified per study protocol.40 Patient demographics and baseline characteristics were balanced across treatment arms, and the patient population in Study A3921133 is generally consistent with the cardiovascular risk factor-enriched patient population from the RA programme (Pfizer data on file).

IRs (95% CI) in an ad hoc safety analysis of the ongoing Study A3921133 (NCT02092467; data cut-off February 2019; database not locked; data have not yet been source-verified or subjected to standard quality-check procedures that would occur at the time of database lock, and may therefore be subject to change) for DVT and PE with tofacitinib 5 mg twice daily, tofacitinib 10 mg twice daily and TNFi are reported in figure 4.1 Compared with TNFi, the hazard ratios (HRs) (95% CI) for DVT/PE with tofacitinib 5 mg twice daily were 1.66 (0.60–4.57)/2.99 (0.81–11.06), and 2.13 (0.80–5.69)/5.96 (1.75–20.33) with tofacitinib 10 mg twice daily.1

Figure 4

Incidence rates (95% CI) for DVT and PE among patients in Study A3921133 (ad hoc safety analysis).a1 aData cut-off February 2019; database not locked. Data have not yet been source-verified or subjected to standard quality-check procedures that would occur at the time of database lock, and may therefore be subject to change. BID, twice daily; DVT, deep vein thrombosis; IR, incidence rate (number of patients with an event per 100 PY of exposure); PE, pulmonary embolism; PY, patient-years; TNFi, tumour necrosis factor inhibitor.

Baseline risk factor analysis

When the individual baseline risk factors for each patient who experienced DVT, PE or ATE in completed studies of the tofacitinib development programmes were evaluated, the most common baseline risk factors in RA patients were C-reactive protein level (CRP) >2.87 mg/L, hypertension, aged ≥60 years and Day 1 use of corticosteroids; in PsO patients, CRP >2.87 mg/L, male sex and BMI ≥30 kg/m2 appeared to be the most common baseline risk factors; events among PsA patients were too low to draw conclusions (online supplementary table S6). It should be noted that active disease was an inclusion criteria for the RA studies, with patients requiring either an erythrocyte sedimentation rate >28 mm/hour or CRP >7 mg/L. The vast majority of patients who experienced a thromboembolic event had multiple baseline risk factors (figure 5).

Figure 5

Number of baseline risk factors for patients who experienced a DVT, PE or ATE in completed studies in the (A) RA, (B) PsO and (C) PsA tofacitinib development programmes, stratified by tofacitinib dose. Those patients who had an event within the predefined risk period (minimum of a patient’s last treatment dose date plus 28 days, date of death or up to the last observation date) are included. Details on the individual risk factors, and the number of patients who experienced each risk factor, are summarised in online supplementary table S6. ATE, arterial thromboembolism; BID, twice daily; DVT, deep vein thrombosis; n, number of patients with a given number of baseline risk factors; PE, pulmonary embolism; PsA, psoriatic arthritis; PsO, psoriasis; RA, rheumatoid arthritis.

Comparison of clinical data and observational data

Patient demographics and baseline characteristics were generally similar between the tofacitinib programmes (table 1) and cohorts within the respective US Corrona registries (online supplementary table S7) and MarketScan database (online supplementary table S8).

Standardised IRs of VTE from the RA, PsA and PsO US Corrona registries were broadly comparable with those in the tofacitinib development programmes (online supplementary table S9). For RA patients in the MarketScan database, IRs were higher than those observed in the tofacitinib programme, but similar between those receiving tofacitinib and bDMARDs within the MarketScan database cohorts (online supplementary table S10).

Baseline demographics and disease characteristics for the subgroup analysis of the Corrona RA registry data of patients with moderate to severe disease activity (CDAI >10) and who were aged ≥50 years with ≥1 cardiovascular risk factor are given in online supplementary table S11. Unadjusted IRs for DVT, PE and VTE (DVT or PE) for bDMARD-initiating (tofacitinib-naïve) patients were higher in those with cardiovascular risk factors than in the overall subgroup population (figure 6); the frequency of VTE events in patients initiating tofacitinib with cardiovascular risk factors versus the overall subgroup population was too low to draw firm conclusions (figure 6).

Figure 6

Drug exposure and unadjusted incidence rates (95% CI) for DVT, PE and VTE (DVT or PE) for RA patients with moderate to severe disease activity (CDAI >10) in the US Corrona RA registry subanalysis who were bDMARDa or tofacitinibb initiators; all patients, stratified by cardiovascular risk factors.c aIncluded patients with moderate to severe RA (CDAI >10 at time of initiation) in the Corrona RA registry initiating a first or subsequent bDMARD (each initiation was considered separately, such that there were multiple initiations per patient) and who were tofacitinib-naïve. bRA patients in the US Corrona registry initiating tofacitinib for the first time. cDefined as patients aged ≥50 years and with ≥1 of the following cardiovascular risk factors: current smoker, diagnosis of hypertension, diagnosis of diabetes mellitus, history of coronary artery disease (eg, cardiac arrest, heart attack, unstable angina, revascularisation procedures), family history of premature coronary heart disease or current extra-articular RA disease. bDMARD, biologic disease-modifying antirheumatic drug; CDAI, Clinical Disease Activity Index; DVT, deep vein thrombosis; IR, incidence rate (number of patients with an event per 100 PY of exposure); N, number of RA patients; n, number of RA patients with events; PE, pulmonary embolism; PY, patient-years; RA, rheumatoid arthritis; VTE, venous thromboembolism.

Among RA patients in the US Corrona registry with moderate to severe disease activity (CDAI >10) who experienced a VTE (figure 5), the median (interquartile range (IQR)) time to first event in patients initiating bDMARDs was 213.1 (91.3–334.8) days for DVT, and 395.7 (213.1–760.9) days for PE. Out of a total of 14 DVT events in patients initiating bDMARDs, four and seven events were reported within 3 and 6 months of bDMARD initiation, respectively; out of 13 PE events, none and three events were reported within 3 and 6 months of bDMARD initiation, respectively.

In patients in the Corrona RA registry with moderate to severe disease activity who were initiating tofacitinib, the time to the only reported DVT event was 608.8 days; and median (IQR) time to PE was 608.8 (91.3–1126.2) days. The DVT event did not occur within 6 months of tofacitinib initiation, and one each of the two reported PE events occurred within 3 and 6 months of initiation.

Postmarketing FAERS data

Based on 1210 unique reports (306 for embolic and thrombotic venous events, 422 for arterial events and 563 for unspecified/mixed vessel events) with tofacitinib FAERS data, this analysis did not identify any SDRs for tofacitinib events of interest at any time point (online supplementary table S12). Most O/E ratios for tofacitinib were <1; many events had an upper bound of <1 of the 90% interval of the O/E (56% of EB95s and 40% of ROR95s for PTs). Although O/E ratios for some events were >1, all were still below the SDR-defined threshold of 2 or were non-significant.

Discussion

The objective of this analysis was to inform about thromboembolic events across large populations of RA, PsO and PsA patients treated with tofacitinib, including analyses of patients stratified by the presence or absence of baseline cardiovascular or VTE risk factors. Analysis of the RA (excluding the ongoing Study A3921133), PsO, and PsA tofacitinib development programmes revealed similar IRs of DVT, PE, VTE (DVT or PE) and ATE events for tofacitinib, placebo, adalimumab (an active control or comparator) and methotrexate in studies of ≤24 months’ duration. There did not appear to be an elevated risk of thromboembolic events in the first 3 months of tofacitinib treatment, shown by the relative comparability of IR in the placebo-controlled cohorts with the other cohorts in the tofacitinib development programmes. This was reflected in data from the US Corrona RA registry, where the median time to DVT or PE was >200 days for bDMARDs and >600 days for tofacitinib. Furthermore, IRs were consistent across tofacitinib 5 and 10 mg twice-daily dose groups in the RA, PsO and PsA development programmes. The IRs of DVT and PE for RA, PsO and PsA were also similar to those reported in the tofacitinib UC programme,42 indicating comparable incidences of thromboembolic events with tofacitinib across diseases.

Across the tofacitinib development programmes, the IRs of DVT or PE in tofacitinib-treated patients from the all tofacitinib cohort (ranges 0.00–0.17 and 0.00–0.15, respectively)—including data from LTE studies with longer cumulative tofacitinib exposure—were consistent with those previously reported for patients with RA (ranges 0.21–0.62 and 0.15–0.26, respectively)19 20 22 and PsA (0.33–0.38 and 0.11–0.12, respectively),22 who were untreated or receiving DMARDs, and for patients with severe PsO (0.36 and 0.11, respectively).22 The IRs of ATE in the all tofacitinib cohort (range 0.22–0.52) were also similar to the IRs of ischaemic stroke (0.3 (95% CI 0.27–0.34))37 and myocardial infarction (0.46 (95% CI 0.41–0.52))48 reported in RA patients.

As expected, subanalyses of the RA, PsO and PsA clinical programmes, stratified by the presence or absence of baseline cardiovascular risk factors, showed that patients with risk factors were more likely to experience thromboembolic events than those without. IRs in patients without risk factors were very low. Most patients who experienced thromboembolic events also had multiple cardiovascular risk factors at baseline.

The IRs of DVT and PE among patients with a baseline cardiovascular risk factor in the RA programme were higher than those without baseline cardiovascular risk factors, and are broadly comparable to those from the ad hoc safety analysis data for Study A3921133 (NCT02092467; data cut-off February 2019; database not locked; data have not yet been source-verified or subjected to standard quality-check procedures that would occur at the time of database lock, and may therefore be subject to change) (figure 7).1 The incidence of PE for tofacitinib 10 mg twice daily was higher in the ad hoc safety analysis of Study A3921133 (0.54 (0.32–0.87))1 than that reported in the overall tofacitinib RA programme for patients with a baseline cardiovascular risk factor (0.24 (0.13–0.41)). In addition, IRs in RA patients with cardiovascular risk factors in the US Corrona RA registry initiating tofacitinib were not higher than in those initiating bDMARDs, and were comparable to those in the RA tofacitinib programme, although the frequency of events was low.

Figure 7

Incidence rates (95% CI) for DVT and PE among patients in the RA development programme, stratified by cardiovascular or VTE risk factors (all tofacitinib cohort),a the ENTRACTE trial43 and Study A3921133.b1 aFinal data as of 18 January 2019. bData cut-off February 2019; database not locked. Data have not yet been source-verified or subjected to standard quality-check procedures that would occur at the time of database lock, and may therefore be subject to change. cOne patient was not counted in the numerators of the IR calculations because the event occurred outside the defined risk period. BID, twice daily; DVT, deep vein thrombosis; IR, incidence rate (number of patients with an event per 100 PY of exposure); NR, not reported; PE, pulmonary embolism; PY, patient-years; RA, rheumatoid arthritis; TNFi, tumour necrosis factor inhibitor.

Study A3921133 is designed to assess differences between tofacitinib doses, maintain patients on the same dose throughout treatment (note patients randomised to tofacitinib 10 mg twice daily had their dose reduced to 5 mg twice daily as per protocol amendment in February 2019),41 and encourage patients to remain in the study after treatment discontinuation. Given the observed incidence of MACE among RA patients using advanced therapies,49–52 an endpoint-driven study such as Study A3921133 was projected to take >10 years if enrolling a non-enriched RA population. Therefore, the study was designed to enrich for cardiovascular risk, and enrolled patients aged ≥50 years and with ≥1 cardiovascular risk factor, with the goal of study completion in <8 years.

While the results of the tofacitinib development programme did not confirm an increased VTE/ATE risk or a dose relationship, it should be noted that although the phase 2 and 3 studies did examine tofacitinib dose differences, they were limited by patient number and observation time. In the LTE studies, patients could switch dose, and did not remain in the study after treatment discontinuation. The primary objective of the LTE studies was to examine long-term safety; they were not designed to formally assess dose differences. Furthermore, not all of the cardiovascular risk factors in the A3921133 eligibility criteria could be applied to the all tofacitinib cohorts, as some information was not collected as per study protocols. None of the studies (including Study A3921133) were specifically designed to assess VTE or ATE risk. A number of potential mechanisms have been investigated to understand the increased rate of PE in Study A3921133, but the exact mechanism remains unclear. Further analyses have been initiated, including biomarker analyses of Study A3921133.41

A recently published randomised, open-label trial (ENTRACTE) evaluated the risk of MACE with the interleukin-6 inhibitor tocilizumab versus the TNFi etanercept in RA patients with an inadequate response to csDMARDs or TNFi therapy, and ≥1 cardiovascular risk factor.43 Similar to Study A3921133, ENTRACTE’s primary endpoints included MACE. The reported IR point estimates for DVT and PE with etanercept are consistent with those reported in the US Corrona RA registry among patients initiating bDMARDs aged ≥50 years and with ≥1 cardiovascular risk factor (0.30 and 0.27 for DVT and PE, respectively), and are higher than those observed with TNFi-treated patients in the ad hoc safety analysis data for Study A3921133 (figure 7).1

RA, PsO and PsA patients with a baseline VTE risk factor were also more likely to experience thromboembolic events than those without. Further analysis of the patients who experienced PE in Study A3921133 is required to understand why IRs of PE were higher with tofacitinib 10 mg twice daily versus TNFi, and if drug class affects VTE risk in patients with pre-existing risk factors. Additional analyses of the different criteria used to define cardiovascular and VTE risk factors could further refine those particular risk factors associated with thromboembolic events.

IRs of DVT, PE or ATE events from the tofacitinib development programmes were similar to age- and sex-standardised IRs from the US Corrona registries. IRs of DVT or PE events were also comparable to those previously reported for RA patients from the US Corrona registry (including tofacitinib-treated patients) in a postapproval safety study.45 The IRs from the MarketScan cohort were consistent with previously reported values,53 and no differences were observed between the tofacitinib and bDMARD cohorts. The events included in the search terms for ATE in the tofacitinib development programme comprised a broad list of PTs for SMQs (including myocardial infarction and stroke), whereas myocardial infarction and stroke events were reported separately for the MarketScan database. Although direct comparisons are limited between the tofacitinib development programme and the MarketScan database, the IRs of myocardial infarction and stroke in the MarketScan database suggest that overall rates of ATE were comparable between the two populations.

As patients with serious concomitant conditions are often excluded from randomised controlled trials (RCTs), real-world evidence would be expected to have higher rates of events of interest. Although data from the US Corrona registries and MarketScan database are not directly comparable with data from RCTs, these observational data were from patients selected on criteria reflecting participants in the tofacitinib development programmes; as such, we consider these appropriate for clinical context.

A published analysis of spontaneous reports in the FAERS database revealed disproportionate reporting frequencies for DVT and PE events with tofacitinib and ruxolitinib, concluding that JAK inhibitors might carry an increased risk of pulmonary thromboembolism.54 Our analysis of FAERS data did not support a signal of increased risk of VTE or ATE with tofacitinib, that is, there were no SDRs for events of interest, although differences exist between study designs, including our choice of a commonly cited SDR-defining threshold of EB05 >247 that was higher than that used in the published analysis. The disproportionality analysis used here provides O/E reporting for hypothesis generation or refinement, not for estimating IRs.

This posthoc analysis was limited by using non-adjudicated data from RA, PsO and PsA tofacitinib development programmes (plus the included RCTs not specifically designed to assess VTE or ATE risk), which limits comparisons between the tofacitinib development programmes and observational data (also not typically adjudicated), as well as precluding analyses on event severity, and event-related hospitalisations and deaths. Additionally, determining causality for hospitalisation and deaths following thromboembolic events is challenging, with unknown additional factors potentially playing a role. While the all tofacitinib cohort was not designed to examine differences between tofacitinib dose, as patients could switch tofacitinib dose in the LTE studies, most patients who entered the RA LTE study (part of the all tofacitinib cohort in the present analysis) received tofacitinib 10 mg twice daily, and the IRs of PE were similar to those in the tofacitinib 5 mg twice daily group, when using either the average- or constant-dose algorithm.55 An important limitation of the average tofacitinib dosing method is that a patient is assigned to the same category throughout their experience in the programme, and thus events may be attributed to a dose category different from the actual dose received at the time of the event. This approach narrows the differences between point estimates for both doses, and confounds the ability to evaluate differences between them. While the constant-dosing method addresses some limitations of average dosing, exposure and events captured after a dose switch are censored from the analysis. This results in a shorter overall tofacitinib exposure, and the risk of confounding by the reasons for discontinuation or dose change. There is also a potential for under-reporting of VTE events, particularly DVTs; a DVT is identified in ≤50% of PE cases, but DVT could go undetected depending on the type of diagnostic testing, or if a DVT embolises before testing.56–58 Moreover, timely access to diagnostic testing may vary by region or country, and may contribute to under-reporting of events. Data from the US Corrona registries provide real-world observational data from a wide variety of geographical sites in the USA; however, as in any observational registry, there is a possibility of channelling bias that is unmeasured with potential underascertainment. Under-reporting of VTE in the tofacitinib development programmes and observational data sources is thus problematic, which could be affected by the identification of VTE as a risk with tofacitinib treatment.

In conclusion, this analysis revealed that the incidence of DVT, PE and ATE in the tofacitinib development programmes (tofacitinib exposure of ≤23 497 PY in RA, ≤8955 PY in PsO and ≤2038 PY in PsA) was consistent with observational data in the US Corrona registries and MarketScan databases that include RA, PsO and PsA patients treated with non-biologic and biologic treatments. IRs of VTE and ATE in the RA, PsO and PsA tofacitinib development programmes were generally higher in patients with cardiovascular or VTE risk factors than in patients without. IRs of PE and DVT observed in patients with a baseline cardiovascular risk factor in the RA programme were similar to the Study A3921133 safety analysis, but with no evidence of differences across tofacitinib doses, which may reflect differences in study design. Future research on DVT, PE and ATE in the tofacitinib development programmes will focus on determining whether there are potential mechanistic explanations for thromboembolism related to tofacitinib use and JAK inhibition. Updates to local labelling of JAK inhibitors, such as tofacitinib, identify VTE as an important risk, and the results of this analysis highlight the importance of tailoring individual treatment while considering the risk factors for thromboembolism.

Acknowledgments

The authors would like to thank the patients, investigators and study teams involved in the tofacitinib development programmes, US Corrona registries and IBM MarketScan research databases. Medical writing support, under the guidance of the authors, was provided by Kate Silverthorne, PhD, and Jennifer Higginson, PhD, CMC Connect, McCann Health Medical Communications and was funded by Pfizer Inc, New York, NY, USA in accordance with Good Publication Practice (GPP3) guidelines (Ann Intern Med 2015;163:461–4).

References

Supplementary materials

  • Supplementary Data

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors All authors provided critical revision of the manuscript. All authors interpreted the results, approved the final draft and had the final decision to submit the manuscript for publication. Pfizer Inc did not control the analysis or interpretation of the study results. Publication of this article was not contingent upon approval by Pfizer Inc.

  • Funding The studies included in this analysis were sponsored by Pfizer Inc, except the US Corrona registry, which was sponsored by Corrona LLC, and the analysis was funded by Pfizer Inc (access to Corrona study data was limited to Corrona, and Corrona statisticians completed all of the analyses).

  • Competing interests PM has received research grants and consulting fees from AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Janssen, Novartis, Pfizer Inc, Sun and UCB; and has participated in speakers’ bureaus for AbbVie, Amgen, Bristol-Myers Squibb, Celgene, Genentech, Janssen, Novartis, Pfizer Inc and UCB. CC-S has received research grants from AbbVie, Bristol-Myers Squibb and Pfizer Inc; and consulting fees from AbbVie, Amgen, Gilead, Pfizer Inc and Regeneron-Sanofi. SC has received consulting fees and other remuneration from AbbVie, Amgen, Boehringer Ingelheim, Gilead, Merck and Pfizer Inc. HY has received research grants from Bristol-Myers Squibb and Pfizer Inc. JK is an employee and shareholder of Corrona LLC; and has received research grants and/or consulting fees from AbbVie, Amgen, Bristol-Myers Squibb, Eli Lilly, Genentech, Novartis, Pfizer Inc, Regeneron and Sanofi. JG is an employee and shareholder of Corrona LLC. WM and AO are employees of Corrona LLC; Corrona has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli Lilly, Genentech, Gilead, Janssen, Merck, Novartis, Ortho Dermatologics, Pfizer Inc, Regeneron and Sun. JRC has received research grants and/or consulting fees from AbbVie, Amgen, Bristol-Myers Squibb, Corrona LLC, Crescendo Bio, Eli Lilly, Janssen, Myriad, Pfizer Inc, Roche and UCB. MH is an employee of Pfizer Inc and owns stock/stock options in Pfizer Inc and in other pharmaceutical companies that may manufacture and/or market drugs mentioned in this article or from the same pharmacological/therapeutic class. LF, JW, KSK, DG, CW, CC, HV, EH, AM and TVJ are employees and shareholders of Pfizer Inc.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.

  • Patient consent for publication All patients provided informed consent.

  • Ethics approval Institutional review board approval was provided by all participating institutions.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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