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Response to: ‘Emergency arising from patients’ fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?’ by Santos-Moreno et al
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  1. Jean W Liew1,
  2. Elizabeth R Graef2,
  3. Jeffrey A Sparks3,
  4. Alfred Hyoungju Kim4
  1. 1Division of Rheumatology, Boston University, Boston, Massachusetts, USA
  2. 2Division of Rheumatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
  3. 3Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA
  4. 4Medicine/Rheumatology, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA
  1. Correspondence to Dr Jeffrey A Sparks, Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA 02115, USA; jsparks{at}bwh.harvard.edu

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We thank Santos-Moreno et al for their response to our commentary.1 2 The authors provide data on cardiovascular adverse events associated with maintenance antimalarial use for patients with rheumatoid arthritis (RA). In addition to our previous correspondence response3 from Erre et al,4 these additional data are reassuring to patients with rheumatic diseases on chronic doses of antimalarials regarding the continued safety of these medications.

However, as we have also addressed in a previous response, the safety profile of antimalarials in patients with COVID-19 infection compared with patients with rheumatic disease may differ widely. Observational data regarding cardiovascular events in hospitalised patients with COVID-19 treated with hydroxychloroquine (HCQ) with or without azithromycin have …

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