Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Felix Renaudin; Lucie Orliaguet; Florence Castelli; François Fenaille; Aurelie Prignon; Fawaz Alzaid; Christele Combes; Aurélie Delvaux; Yasmina Adimy; Martine Cohen-Solal; Pascal Richette; Thomas Bardin; Jean-Pierre Riveline; Nicolas Venteclef; Frédéric Lioté; Laure Campillo-Gimenez; Hang-Korng Ea

doi:10.1136/annrheumdis-2020-217342

Article info

Crystal arthropathies

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Authors

Felix Renaudin Universite de Paris, Paris, France INSERM, UMR-S 1132, F-75010, Paris, France PubMed articles Google scholar articles
Lucie Orliaguet Universite de Paris, Paris, France INSERM, Immunity and Metabolism in Diabetes Laboratory, Centre de Recherche des Cordelier, Paris, France PubMed articles Google scholar articles
Florence Castelli Service de Pharmacologie et immunoanalyse (SPI), Laboratoire d'Etude du Métabolisme des Médicaments, CEA, INRAE, Université Paris Saclay, Gif-Sur-Yvette, France PubMed articles Google scholar articles
François Fenaille Service de Pharmacologie et immunoanalyse (SPI), Laboratoire d'Etude du Métabolisme des Médicaments, CEA, INRAE, Université Paris Saclay, Gif-Sur-Yvette, France PubMed articles Google scholar articles
Aurelie Prignon UMS28 Phénotypage du Petit Animal, Laboratoire d'Imagerie Moléculaire Positonique (LIMP), F-75020, Sorbonne Université, Paris, France PubMed articles Google scholar articles
Fawaz Alzaid Universite de Paris, Paris, France INSERM, Immunity and Metabolism in Diabetes Laboratory, Centre de Recherche des Cordelier, Paris, France PubMed articles Google scholar articles
Christele Combes UMR 5085 INPT-UPS-CNRS, Université de Toulouse, ENSIACET, F-31000, Toulouse, France PubMed articles Google scholar articles
Aurélie Delvaux Service de Pharmacologie et immunoanalyse (SPI), Laboratoire d'Etude du Métabolisme des Médicaments, CEA, INRAE, Université Paris Saclay, Gif-Sur-Yvette, France PubMed articles Google scholar articles
Yasmina Adimy Service de Pharmacologie et immunoanalyse (SPI), Laboratoire d'Etude du Métabolisme des Médicaments, CEA, INRAE, Université Paris Saclay, Gif-Sur-Yvette, France PubMed articles Google scholar articles
Martine Cohen-Solal Universite de Paris, Paris, France Bone and Joint Laboratory, INSERM U1132, Paris, France PubMed articles Google scholar articles
Pascal Richette Universite de Paris, Paris, France INSERM, UMR-S 1132, F-75010, Paris, France PubMed articles Google scholar articles
Thomas Bardin Universite de Paris, Paris, France INSERM, UMR-S 1132, F-75010, Paris, France PubMed articles Google scholar articles
Jean-Pierre Riveline Universite de Paris, Paris, France INSERM, Immunity and Metabolism in Diabetes Laboratory, Centre de Recherche des Cordelier, Paris, France PubMed articles Google scholar articles
Nicolas Venteclef Universite de Paris, Paris, France INSERM, Immunity and Metabolism in Diabetes Laboratory, Centre de Recherche des Cordelier, Paris, France PubMed articles Google scholar articles
Frédéric Lioté Universite de Paris, Paris, France INSERM, UMR-S 1132, F-75010, Paris, France PubMed articles Google scholar articles
Laure Campillo-Gimenez Universite de Paris, Paris, France INSERM, UMR-S 1132, F-75010, Paris, France PubMed articles Google scholar articles
Hang-Korng Ea Universite de Paris, Paris, France INSERM, UMR-S 1132, F-75010, Paris, France PubMed articles Google scholar articles

Correspondence to Pr Hang-Korng Ea, Rheumatology, Lariboisiere Hospital, Paris 75010, France; korngea{at}yahoo.fr

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Citation

Renaudin F, Orliaguet L, Castelli F, et al

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Annals of the Rheumatic Diseases 2020;79:1506-1514.

Publication history

Received March 14, 2020
Revised May 25, 2020
Accepted June 25, 2020
First published July 22, 2020.

Online issue publication

April 04, 2023

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