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Response to: ‘Immune-mediated necrotizing myopathies and interstitial lung disease are predominant characteristics in anti-Ku positive patients with idiopathic inflammatory myopathies’ by Yang et al
  1. Lionel Spielmann1,
  2. Benoit Nespola2,
  3. Alain Meyer3,4,5
  1. 1Service de Rhumatologie, Hôpitaux civils de Colmar, Colmar, France
  2. 2Laboratoire d'immunologie, Hopitaux universitaires de Strasbourg, Strasbourg, France
  3. 3Exploration fonctionnelle musculaire, Service de physiologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
  4. 4Centre National de Référence des Maladies Auto-Immunes Systémiques Rares de l'Est et du Sud-Ouest, Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
  5. 5Fédération de médecine translationnelle de Strasbourg, FRU 6702, Université de Strasbourg, Strasbourg, France
  1. Correspondence to Dr Lionel Spielmann, Service de Rhumatologie, Hospices civils de Colmar, Colmar, Alsace 68024, France; lionel.spielmann{at}

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We would like to thank Yang et al1 for their rewarding comment on our work, in which we report that patients harbouring anti-Ku autoantibodies with elevated serum levels of creatine kinase (elevated CK) are at risk of interstitial lung disease (ILD), whereas anti-Ku patients with anti-dsDNA are frequently affected by systemic lupus erythematosus and are at risk of glomerulonephritis.2

Yang et al retrospectively investigated 1214 patients with myositis (defined on Bohan and Peter criteria) in a single Chinese centre. Twenty-one patients (1.7%) had anti-Ku antibodies, defined as a fine speckled pattern seen at immunofluorescence, together with positive commercial assay results.

In accordance with …

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