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Correspondence
Correspondence on ‘Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor’ by Ishikawa et al
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  1. Cristina Regueiro,
  2. Antonio Gonzalez
  1. Experimental and Observational Rheumatology, Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
  1. Correspondence to Dr Antonio Gonzalez, Experimental and Observational Rheumatology, Hospital Clinico Universitario de Santiago, Santiago de Compostela 15706, Spain; agmartinezp{at}ser.es

https://doi.org/10.1136/annrheumdis-2019-216849

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    We read with great interest the paper of Ishikawa et al,1 which addressed the link between smoking and the levels of anti-citrullinated protein antibodies(ACPA) and rheumatoid factor (RF) in a total of 6239 Japanese rheumatoid arthritis (RA) patients. We particularly appreciate the detailed smoking history collected that allowed a very detailed analysis. The authors collected information about the number of cigarette packs smoked per day, the years smoking and the time of smoke cessation when it was present. They also distinguished the ever smoker patients in three categories: smokers at disease onset, ex-smokers before onset and smokers after onset, which looks like a very …

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